Fu Yu, Pan Yunbao, Li Zhiqiang, Li Yirong
Department of Clinical Laboratory, Zhongnan Hospital, Wuhan University, Wuhan, China.
Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Front Microbiol. 2021 Jan 13;11:603058. doi: 10.3389/fmicb.2020.603058. eCollection 2020.
The Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has now become a global pandemic due to its high transmissibility. The unavoidable shortcomings of traditional diagnostic assay, including nucleic acid testing, diverse serological assays characterized by high-throughput and less workload, are playing a more and more crucial role to supplement the nucleic acid test. In this review, we summarize the dynamic change of the specific IgM, IgG, and IgA antibodies against SARS-CoV-2 as well as neutralizing antibodies and discuss the clinical utility and limitations of the different serological assays. SARS-CoV-2, a newly discovered virus, shows some unique pathogenetic and epidemiological characteristics that have not been completely understood so far. Currently, studies about the antibody responses against SARS-CoV-2 and the clinical utility of serological testing are increasing. It's well suggested that the combination of serological tests and nucleic acid tests can cohesively improve the testing efficiency for identifying COVID-19 suspected patients.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）因其高传播性现已成为全球大流行疾病。传统诊断检测方法（包括核酸检测）存在不可避免的缺点，以高通量和工作量少为特点的多种血清学检测方法在补充核酸检测方面正发挥着越来越关键的作用。在本综述中，我们总结了针对SARS-CoV-2的特异性IgM、IgG和IgA抗体以及中和抗体的动态变化，并讨论了不同血清学检测方法的临床应用和局限性。SARS-CoV-2是一种新发现的病毒，具有一些独特的致病和流行病学特征，目前尚未完全明确。目前，关于针对SARS-CoV-2的抗体反应以及血清学检测临床应用的研究正在增加。有充分证据表明，血清学检测与核酸检测相结合可以有效提高COVID-19疑似患者的检测效率。
