Khan Tariq, Khan Mubarak Ali, Mashwani Zia-Ur-Rehman, Ullah Nazif, Nadhman Akhtar
Department of Biotechnology, University of Malakand, Chakdara, KP, Pakistan.
Department of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan (AWKUM), Mardan, 23390, Pakistan.
Biocatal Agric Biotechnol. 2021 Jan;31:101890. doi: 10.1016/j.bcab.2020.101890. Epub 2020 Dec 11.
There are numerous trials underway to find treatment for the COVID-19 through testing vaccines as well as existing drugs. Apart from the many synthetic chemical compounds, plant-based compounds could provide an array of \suitable candidates for testing against the virus. Studies have confirmed the role of many plants against respiratory viruses when employed either as crude extracts or their active ingredients in pure form. The purpose of this review article is to highlight the importance of phytomedicine against COVID-19. The main aim is to review the mechanistic aspects of most important phytochemical compounds that have showed potential against coronaviruses. Glycyrrhizin from the roots of has shown promising potential against the previously epidemic coronavirus, SARS-CoV. Other important plants such as , , , and spp. have been employed against SARS-CoV. Active ingredients (e.g. emodin, reserpine, aescin, myricetin, scutellarin, apigenin, luteolin, and betulonic acid) have shown promising results against the coronaviruses. Phytochemicals have demonstrated activity against the coronaviruses through mechanisms such as viral entry inhibition, inhibition of replication enzymes and virus release blockage. However, compared to synthetic drugs, phytomedicine are mechanistically less understood and should be properly evaluated before application. Nonetheless, phytochemicals reduce the tedious job of drug discovery and provide a less time-consuming alternative for drug testing. Therefore, along with other drugs currently tested against COVID-19, plant-based drugs should be included for speedy development of COVID-19 treatment.
目前正在进行大量试验，通过测试疫苗以及现有药物来寻找治疗新冠病毒的方法。除了众多合成化合物外，植物性化合物也可为针对该病毒的测试提供一系列合适的候选物。研究证实，许多植物无论是以粗提物形式还是以其纯形式的活性成分形式使用，都对呼吸道病毒有作用。这篇综述文章的目的是强调植物医学在对抗新冠病毒方面的重要性。主要目的是回顾已显示出对冠状病毒有潜在作用的最重要植物化学化合物的作用机制方面。甘草根中的甘草酸已显示出对先前流行的冠状病毒——严重急性呼吸综合征冠状病毒（SARS-CoV）有潜在的良好作用。其他重要植物，如……（此处原文有缺失植物名称）等已被用于对抗SARS-CoV。活性成分（如大黄素、利血平、七叶皂苷、杨梅素、野黄芩苷、芹菜素、木犀草素和桦木酸）已显示出对冠状病毒有良好效果。植物化学物质通过病毒进入抑制、复制酶抑制和病毒释放阻断等机制对冠状病毒表现出活性。然而，与合成药物相比，植物医学的作用机制尚不太清楚，在应用前应进行适当评估。尽管如此，植物化学物质减少了药物发现的繁琐工作，并为药物测试提供了一种耗时较少的替代方法。因此，与目前正在测试用于对抗新冠病毒的其他药物一起，植物性药物应被纳入，以加速新冠病毒治疗方法的研发。
