Liyen Cartelle Anabel, Uy Pearl Princess, Koehler Tara E, Yap John Erikson L
Department of Medicine, Medical College of Georgia - Augusta University, Augusta, USA.
Gastroenterology and Hepatology, Medical College of Georgia - Augusta University, Augusta, USA.
Cureus. 2020 Dec 26;12(12):e12309. doi: 10.7759/cureus.12309.
The discovery of the pathological role of in various disease states, such as peptic ulcer disease (PUD) and Mucosa Associated Lymphoid Tissue (MALT) lymphoma, was ground-breaking in the field of gastroenterology. Given the potentially dire clinical implications of chronic infection, it is important to achieve complete eradication. More importantly, the rising prevalence of antimicrobial resistance, similar to other pathogens world-wide, is of particular concern. Despite evidence supporting the growing threat of antimicrobial resistance, clinically, it is also important to survey just how much of the failed treatment is truly a reflection of resistance versus poor treatment adherence. In this report, we detail the case of a 64-year-old female who was previously given six treatment courses for persistent infection. Successful eradication was achieved with rifabutin triple therapy consisting of high-dose amoxicillin and strict adherence monitoring by a clinical pharmacist. This case highlights the importance of patient education, medication reconciliation, and close monitoring to ensure successful treatment of persistent infection.
在各种疾病状态中，如消化性溃疡病（PUD）和黏膜相关淋巴组织（MALT）淋巴瘤，[病原体名称]病理作用的发现是胃肠病学领域的突破性进展。鉴于慢性[病原体名称]感染可能产生的严重临床后果，实现彻底根除至关重要。更重要的是，与世界其他病原体类似，[病原体名称]抗菌药物耐药性的日益普遍尤其令人担忧。尽管有证据支持抗菌药物耐药性构成的日益严重威胁，但在临床上，调查有多少治疗失败真正是由于耐药性而非治疗依从性差也很重要。在本报告中，我们详细介绍了一名64岁女性的病例，该女性此前因持续性[病原体名称]感染接受了六个疗程的治疗。通过由高剂量阿莫西林组成的利福布汀三联疗法以及临床药师的严格依从性监测，成功实现了根除。该病例凸显了患者教育、用药核对以及密切监测对于确保持续性[病原体名称]感染成功治疗的重要性。
