用于神经接口的碳纳米管修饰微电极阵列

Vafaiee Mohaddeseh, Mohammadpour Raheleh, Vossoughi Manouchehr, Asadian Elham, Janahmadi Mahyar, Sasanpour Pezhman

Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran.

Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.

Front Bioeng Biotechnol. 2021 Jan 13;8:582713. doi: 10.3389/fbioe.2020.582713. eCollection 2020.

Carbon nanotubes (CNTs) coatings have been shown over the past few years as a promising material for neural interface applications. In particular, in the field of nerve implants, CNTs have fundamental advantages due to their unique mechanical and electrical properties. In this study, carbon nanotubes multi-electrode arrays (CNT-modified-Au MEAs) were fabricated based on gold multi-electrode arrays (Au-MEAs). The electrochemical impedance spectra of CNT-modified-Au MEA and Au-MEA were compared employing equivalent circuit models. In comparison with Au-MEA (17 Ω), CNT-modified-Au MEA (8 Ω) lowered the overall impedance of the electrode at 1 kHz by 50%. The results showed that CNT-modified-Au MEAs have good properties such as low impedance, high stability and durability, as well as scratch resistance, which makes them appropriate for long-term application in neural interfaces.

在过去几年中，碳纳米管（CNTs）涂层已被证明是一种用于神经接口应用的有前途的材料。特别是在神经植入领域，由于其独特的机械和电学性质，碳纳米管具有基本优势。在本研究中，基于金多电极阵列（Au-MEAs）制备了碳纳米管多电极阵列（CNT修饰的Au MEA）。采用等效电路模型比较了CNT修饰的Au MEA和Au-MEA的电化学阻抗谱。与Au-MEA（17Ω）相比，CNT修饰的Au MEA（8Ω）在1kHz时将电极的总阻抗降低了50%。结果表明，CNT修饰的Au MEA具有低阻抗、高稳定性和耐久性以及耐刮性等良好性能，这使其适用于神经接口的长期应用。