Schwille Petra
Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
Emerg Top Life Sci. 2019 Nov 11;3(5):551-558. doi: 10.1042/ETLS20190023.
Cell division is one of the most fundamental processes of life, and so far the only known way of how living systems can come into existence at all. Consequently, its reconstitution in any artificial cell system that will have to be built from the bottom-up is a notoriously complex but an important task. In this short review, I discuss several approaches how to realize division of cell-like compartments, from simply relying on the physical principles of destabilization by growth, or applying external forces, to the design of self-assembling and self-organizing machineries that may autonomously accomplish this task in response to external or internal cues.
细胞分裂是生命最基本的过程之一，也是迄今为止已知的生命系统得以产生的唯一方式。因此，在任何必须自下而上构建的人工细胞系统中对其进行重构，都是一项极其复杂但又很重要的任务。在这篇简短的综述中，我讨论了几种实现类细胞隔室分裂的方法，从单纯依靠生长导致不稳定的物理原理，或施加外力，到设计能够根据外部或内部线索自主完成这项任务的自组装和自组织机制。
