Sun Yat-Sen University, Guangzhou, China.
Adv Exp Med Biol. 2021;1300:41-62. doi: 10.1007/978-981-33-4187-6_3.
Endocrine-disrupting chemicals (EDCs) exist ubiquitously in the environment. Epidemiological data suggest that the increasing prevalence of infertility may be related to the numerous chemicals. Exposure to EDCs may have significant adverse impacts on the reproductive system including fertility, ovarian reserve, and sex steroid hormone levels. This chapter covers the common exposure ways, the origins of EDCs, and their effects on ovarian function, follicular genesis, and oocyte quality. Furthermore, we will review the origin and the physiology of ovarian development, as well as explore the mechanisms in which EDCs act on the ovary from human and animal data. And then, we will focus on the bisphenol A (BPA), which has been shown to reduce fertility and ovarian reserve, as well as disrupt steroidogenesis in animal and human models. Finally, we will discuss the future direction of prevention and solution methods.
内分泌干扰化学物质（EDCs）广泛存在于环境中。流行病学数据表明，不孕症的患病率不断上升可能与众多化学物质有关。接触内分泌干扰化学物质可能对生殖系统产生重大的不良影响，包括生育能力、卵巢储备和性激素水平。本章涵盖了常见的暴露途径、内分泌干扰化学物质的来源，以及它们对卵巢功能、卵泡发生和卵母细胞质量的影响。此外，我们将回顾卵巢发育的起源和生理学，并从人类和动物数据中探讨内分泌干扰化学物质作用于卵巢的机制。然后，我们将重点讨论双酚 A（BPA），它已被证明会降低生育能力和卵巢储备，并扰乱动物和人类模型中的类固醇生成。最后，我们将讨论预防和解决方法的未来方向。
