Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Acta Biomed. 2020 Nov 10;91(4):e2020142. doi: 10.23750/abm.v91i4.10159.
The novel coronavirus disease (COVID-19) has affected people around the world both physically and psychologically. As result, developing coronavirus-specific vaccine and/or therapeutics is now a top priority for public health agencies. Since our findings about COVID-19 are relatively new, the current knowledge about the molecular mechanism involved in pathogenicity and virulence of the novel coronavirus is not advanced. Understanding angiotensin-converting enzyme 2 (ACE2), the receptor for the coronavirus, is significantly important. To better illustrate the role of ACE2 in the severity of COVID-19 and the impact of currently used drugs on this receptor, this paper briefly reviews newly published articles in this regard.
新型冠状病毒病（COVID-19）在身体和心理两方面影响着全世界的人们。因此，开发针对冠状病毒的疫苗和/或疗法现在是公共卫生机构的首要任务。由于我们对 COVID-19 的了解相对较新，目前关于新型冠状病毒致病性和毒力涉及的分子机制的知识还不够先进。了解血管紧张素转换酶 2（ACE2），即冠状病毒的受体，具有重要意义。为了更好地说明 ACE2 在 COVID-19 严重程度中的作用，以及目前使用的药物对该受体的影响，本文简要回顾了这方面新发表的文章。
