探索非编码RNA在自噬中的作用。
Exploring the role of non-coding RNAs in autophagy.
作者信息
Ghafouri-Fard Soudeh, Shoorei Hamed, Mohaqiq Mahdi, Majidpoor Jamal, Moosavi Mohammad Amin, Taheri Mohammad
机构信息
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
出版信息
Autophagy. 2022 May;18(5):949-970. doi: 10.1080/15548627.2021.1883881. Epub 2021 Feb 18.
As a self-degradative mechanism, macroautophagy/autophagy has a role in the maintenance of energy homeostasis during critical periods in the development of cells. It also controls cellular damage through the eradication of damaged proteins and organelles. This process is accomplished by tens of ATG (autophagy-related) proteins. Recent studies have shown the involvement of non-coding RNAs in the regulation of autophagy. These transcripts mostly modulate the expression of genes. Both long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been shown to modulate the autophagy mechanism. Levels of several lncRNAs and miRNAs are altered in this process. In the present review, we discuss the role of lncRNAs and miRNAs in the regulation of autophagy in diverse contexts such as cancer, deep vein thrombosis, spinal cord injury, diabetes and its complications, acute myocardial infarction, osteoarthritis, pre-eclampsia and epilepsy.: AMI: acute myocardial infarction; ATG: autophagy-related; lncRNA: long non-coding RNA; miRNA: microRNA.
作为一种自我降解机制，巨自噬/自噬在细胞发育的关键时期对维持能量稳态发挥作用。它还通过清除受损蛋白质和细胞器来控制细胞损伤。这一过程由数十种自噬相关（ATG）蛋白完成。最近的研究表明非编码RNA参与自噬的调控。这些转录本大多调节基因表达。长链非编码RNA（lncRNA）和微小RNA（miRNA）均已被证明可调节自噬机制。在此过程中，几种lncRNA和miRNA的水平会发生改变。在本综述中，我们讨论lncRNA和miRNA在多种情况下对自噬调控的作用，如癌症、深静脉血栓形成、脊髓损伤、糖尿病及其并发症、急性心肌梗死、骨关节炎、子痫前期和癫痫。：AMI：急性心肌梗死；ATG：自噬相关；lncRNA：长链非编码RNA；miRNA：微小RNA
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