Chromosomal damage induced by maleic hydrazide in mammalian cells in vitro and in vivo.

作者信息

Meschini R, Quaranta M T, Fiore M, Polcaro C, Possagno E, Palitti F

机构信息

C.N.R., Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Roma, Italy.

出版信息

Mutat Res. 1988 Apr;204(4):645-8. doi: 10.1016/0165-1218(88)90067-5.

The induction of sister-chromatid exchanges (SCE) and chromosomal aberrations (Ch.Ab.) by the herbicide maleic hydrazide (MH) has been investigated in Chinese hamster ovary (CHO) cells grown in vitro and in bone marrow cells of mice treated in vivo. MH induces SCE and Ch.Ab. in CHO cells without metabolic activation; however, no induction of SCE was found in the in vivo experiments.