Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Cancer Gene Ther. 2021 Dec;28(12):1376-1389. doi: 10.1038/s41417-020-00285-2. Epub 2021 Feb 2.
Accumulating evidence has been obtained to understand the mechanisms of long non-coding RNAs (lncRNAs) in bladder cancer (BC). However, due to the recurrence and metastasis of BC, searching for lncRNAs that are related to prognosis and metastasis and exploring the pathogenesis of BC might provide new insights for the treatment of BC. In the present study, we used the TCGA and GEO databases and identified LINC02446 as associated with prognosis and differentially expressed in bladder cancer tissues and para-cancer tissues. Then, we found that LINC02446 could affect the proliferation, migration and invasion of BC cells. Additionally, we found that LINC02446 could bind to the EIF3G protein and regulate the protein stability of EIF3G and then inhibit the mTOR signalling pathway. In summary, all these findings show that LINC02446 might serve as a promising therapeutic target for BC intervention.
越来越多的证据已经被获得，以了解长链非编码 RNA（lncRNAs）在膀胱癌（BC）中的作用机制。然而，由于 BC 的复发和转移，寻找与预后和转移相关的 lncRNAs，并探索 BC 的发病机制，可能为 BC 的治疗提供新的见解。在本研究中，我们使用 TCGA 和 GEO 数据库，确定 LINC02446 与膀胱癌组织和癌旁组织中的预后相关，并在其中差异表达。然后，我们发现 LINC02446 可以影响 BC 细胞的增殖、迁移和侵袭。此外，我们发现 LINC02446 可以与 EIF3G 蛋白结合，并调节 EIF3G 蛋白的稳定性，从而抑制 mTOR 信号通路。总之，这些发现表明 LINC02446 可能成为 BC 干预的一个有前途的治疗靶点。
