Health Sciences Division, Abu Dhabi Women's College, Higher Colleges of Technology, 41012 Abu Dhabi, UAE.
Department of Avian Disease Research and Diagnostic, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj 31585-854, Iran.
Molecules. 2021 Jan 26;26(3):628. doi: 10.3390/molecules26030628.
The emergence of antimicrobial resistance (AMR) has urged researchers to explore therapeutic alternatives, one of which includes the use of natural plant products such as essential oils (EO). In fact, EO obtained from clove, oregano, thymus, cinnamon bark, rosemary, eucalyptus, and lavender have been shown to present significant inhibitory effects on bacteria, fungi, and viruses; many studies have been done to measure EO efficacy against microorganisms. The strategy of combinatory effects via conventional and non-conventional methods revealed that the combined effects of EO-EO or EO-antibiotic exhibit enhanced efficacy. This paper aims to review the antimicrobial effects of EO, modes of EO action (membrane disruption, efflux inhibition, increase membrane permeability, and decrease in intracellular ATP), and their compounds' potential as effective agents against bacteria, fungi, and viruses. It is hoped that the integration of EO applications in this work can be used to consider EO for future clinical applications.
抗菌药物耐药性（AMR）的出现促使研究人员探索治疗替代方法，其中包括使用天然植物产品，如精油（EO）。事实上，从丁香、牛至、百里香、肉桂、迷迭香、桉树和薰衣草中提取的 EO 已被证明对细菌、真菌和病毒具有显著的抑制作用；许多研究已经测量了 EO 对微生物的功效。通过常规和非常规方法的协同作用策略表明，EO-EO 或 EO-抗生素的联合作用具有增强的功效。本文旨在综述 EO 的抗菌作用、EO 的作用模式（膜破坏、外排抑制、增加膜通透性和减少细胞内 ATP）及其化合物作为有效对抗细菌、真菌和病毒的潜在作用。希望这项工作中 EO 的应用整合可以考虑将 EO 用于未来的临床应用。
