Rahbarghazi Afshin, Siahkouhian Marefat, Rahbarghazi Reza, Ahmadi Mahdi, Bolboli Lotfali, Keyhanmanesh Rana, Mahdipour Mahdi, Rajabi Hadi
Department of Physical Education and Sports Sciences, Faculty of Educational Science & Psychology, University of Mohaghegh Ardabili, Daneshgah Street, Ardabil, Iran.
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Inflamm (Lond). 2021 Feb 2;18(1):4. doi: 10.1186/s12950-021-00269-5.
Melatonin possesses multi-organ and pleiotropic effects with potency to control angiogenesis at both molecular and cellular levels. To date, many efforts have been made to control and regulate the dynamic of angiogenesis modulators in a different milieu. The term angiogenesis or neovascularization refers to the development of de novo vascular buds from the pre-existing blood vessels. This phenomenon is tightly dependent on the balance between the pro- and anti-angiogenesis factors which alters the functional behavior of vascular cells. The promotion of angiogenesis is thought to be an effective strategy to accelerate the healing process of ischemic changes such as infarcted myocardium. Of note, most of the previous studies have focused on the anti-angiogenesis capacity of melatonin in the tumor niche. To the best of our knowledge, few experiments highlighted the melatonin angiogenesis potential and specific regulatory mechanisms in the cardiovascular system. Here, we aimed to summarize some previous experiments related to the application of melatonin in cardiovascular diseases such as ischemic injury and hypertension by focusing on the regulatory mechanisms.
褪黑素具有多器官和多效性作用，能够在分子和细胞水平上控制血管生成。迄今为止，人们已经做出了许多努力来控制和调节不同环境中血管生成调节剂的动态变化。血管生成或新生血管形成一词是指从预先存在的血管中发育出新的血管芽。这种现象紧密依赖于促血管生成因子和抗血管生成因子之间的平衡，而这种平衡会改变血管细胞的功能行为。促进血管生成被认为是加速缺血性改变（如梗死心肌）愈合过程的有效策略。值得注意的是，之前的大多数研究都集中在褪黑素在肿瘤微环境中的抗血管生成能力上。据我们所知，很少有实验强调褪黑素在心血管系统中的血管生成潜力和特定调节机制。在这里，我们旨在通过关注调节机制，总结一些先前与褪黑素在心血管疾病（如缺血性损伤和高血压）中的应用相关的实验。
