Ma Yicong, Xie Jing, Wijaya Chandra Sugiarto, Xu Suhong
The Zhejiang University-University of Edinburgh Institute and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Center for Stem Cell and Regenerative Medicine, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, China.
Cell Regen. 2021 Feb 3;10(1):5. doi: 10.1186/s13619-020-00067-z.
As a result of evolution, the ability to repair wounds allows organisms to combat environment insults. Although the general process of wound healing at the tissue level has been described for decades, the detailed molecular mechanisms regarding the early wound response and rapid wound repair at the cellular level remain little understood. Caenorhabditis elegans is a model organism widely used in the field of development, neuroscience, programmed cell death etc. The nematode skin is composed of a large epidermis associated with a transparent extracellular cuticle, which likely has a robust capacity for epidermal repair. Yet, until the last decades, relatively few studies had directly analyzed the wound response and repair process. Here we review recent findings in how C. elegans epidermis responds to wounding and initiates early actin-polymerization-based wound closure as well as later membrane repair. We also discussed some remained outstanding questions for future study.
进化的结果是，修复伤口的能力使生物体能够抵御环境伤害。尽管几十年来人们已经描述了组织水平上伤口愈合的一般过程，但关于细胞水平上早期伤口反应和快速伤口修复的详细分子机制仍知之甚少。秀丽隐杆线虫是一种在发育、神经科学、程序性细胞死亡等领域广泛使用的模式生物。线虫的皮肤由与透明细胞外角质层相关的大表皮组成，表皮可能具有强大的修复能力。然而，直到过去几十年，相对较少的研究直接分析了伤口反应和修复过程。在这里，我们综述了关于秀丽隐杆线虫表皮如何对伤口做出反应并启动基于肌动蛋白聚合的早期伤口闭合以及后期膜修复的最新发现。我们还讨论了一些有待未来研究解决的突出问题。
