探索烧伤患者样本中 EQ-5D-5L 疼痛/不适与疼痛和瘙痒之间的关系。
Exploring the relation between the EQ-5D-5L pain/discomfort and pain and itching in a sample of burn patients.
机构信息
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands.
Association of Dutch Burn Centres, Maasstad Hospital, Rotterdam, the Netherlands.
出版信息
Health Qual Life Outcomes. 2020 May 19;18(1):144. doi: 10.1186/s12955-020-01394-0.
BACKGROUND
The EQ-5D domain pain/discomfort (PD) uses one item to capture pain and other aspects of discomfort, like itching. This study explored how pain, itching and the EQ-5D-5L PD domain relate to each other in a sample of burn patients.
METHODS
Adult burn patients completed the EQ-5D-5L and the Patient and Observer Scar Assessment Scale (POSAS) 5-7 years after sustaining their injury. The POSAS includes a separate pain and an itching item. Spearman's correlation coefficient established the association between the EQ-5D-5L PD and the POSAS pain and itching item. With multivariable regression analysis the linear association between the POSAS pain and itching item and EQ-5D-5L PD domain was tested.
RESULTS
Data from 245 patients were included. Mean EQ-5D-5L index value was 0.87 and 39.2% reported at least slight problems on the EQ-5D-5L PD domain. Most patients gave corresponding answers on the EQ-5D-5L PD domain and on the POSAS pain (73%) and itching (70%) item. Spearman correlation coefficients of the EQ-5D-5L PD domain with the POSAS pain and itching were 0.468 (p < 0.001) and 0.473 (p < 0.001), respectively. Among respondents with pain and without itching and respondents with itching and without pain, Spearman correlation coefficients were 0.585 (p = 0.076) and 0.408 (p = 0.001), respectively. POSAS pain (unstandardized Beta = 0.14) and POSAS itching (unstandardized Beta = 0.08) were significantly associated with EQ-5D-5L PD domain (p < 0.001).
CONCLUSIONS
Our findings indicate that, in a sample of burn patients, pain and itching are captured by the broader EQ-5D-5L PD domain. The EQ-5D-5L PD domain can thus be used to assess pain and itching in relation to HRQL, but the POSAS pain and itching items are more sensitive. The EQ-5D-5L is, however, no replacement of the POSAS when the POSAS is used for its primary aim; assessment of scar quality.
TRIAL REGISTRATION
Netherlands Trial Register (NTR6407).
背景
EQ-5D 量表疼痛/不适（PD）使用一个项目来捕捉疼痛和不适的其他方面，如瘙痒。本研究旨在探讨在烧伤患者样本中，疼痛、瘙痒和 EQ-5D-5L PD 域之间的相互关系。
方法
成人烧伤患者在受伤后 5-7 年完成 EQ-5D-5L 和患者和观察者瘢痕评估量表（POSAS）5-7。POSAS 包括一个单独的疼痛和瘙痒项目。Spearman 相关系数确定了 EQ-5D-5L PD 与 POSAS 疼痛和瘙痒项目之间的关联。通过多变量回归分析，测试了 POSAS 疼痛和瘙痒项目与 EQ-5D-5L PD 域之间的线性关联。
结果
共纳入 245 例患者。EQ-5D-5L 指数值的平均值为 0.87，39.2%的患者在 EQ-5D-5L PD 域报告至少有轻微的问题。大多数患者对 EQ-5D-5L PD 域和 POSAS 疼痛（73%）和瘙痒（70%）项目做出了相应的回答。EQ-5D-5L PD 域与 POSAS 疼痛和瘙痒的 Spearman 相关系数分别为 0.468（p<0.001）和 0.473（p<0.001）。在有疼痛而无瘙痒的患者和有瘙痒而无疼痛的患者中，Spearman 相关系数分别为 0.585（p=0.076）和 0.408（p=0.001）。POSAS 疼痛（未标准化 Beta=0.14）和 POSAS 瘙痒（未标准化 Beta=0.08）与 EQ-5D-5L PD 域显著相关（p<0.001）。
结论
我们的研究结果表明，在烧伤患者样本中，疼痛和瘙痒由更广泛的 EQ-5D-5L PD 域捕捉。因此，EQ-5D-5L PD 域可用于评估与 HRQL 相关的疼痛和瘙痒，但 POSAS 疼痛和瘙痒项目更敏感。然而，当 POSAS 用于其主要目的（评估瘢痕质量）时，EQ-5D-5L 并不能替代 POSAS。
试验注册
荷兰试验注册库（NTR6407）。
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