College of Medicine, University of Arizona, Tucson, Arizona, USA.
David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Dermatology. 2021;237(3):357-364. doi: 10.1159/000514027. Epub 2021 Feb 3.
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis characterized by painful nodules, abscesses, sinus tracts, and scarring mainly in the intertriginous areas. Patients with HS often experience inadequate responses to traditional treatment consisting of lifestyle modification, topical and systemic antibiotics, hormonal modulators, biologics, and procedural modalities. Low-dose radiotherapy has been used in benign cutaneous conditions, including HS; however, there is a paucity of literature summarizing its evidence. Herein, we systematically review the current literature on the efficacy of radiotherapy for patients with HS.
This systematic review of the published literature reports the patient demographics, treatment regimens, efficacy, and adverse effects of radiotherapy in the treatment of HS. The historic timeline of these publications highlights the changes in management recommendations, introduction of more standardized outcome measures, and enhancements in treatment options. Radiotherapy appears to be an option for patients with treatment-resistant HS or who are poor surgical candidates. However, there remains a paucity of consensus on proper candidate selection, dosing, efficacy, and safety of the short- and long-term effects of radiotherapy.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，其特征为疼痛性结节、脓肿、窦道和瘢痕，主要发生在皱褶部位。HS 患者常对包括生活方式改变、局部和全身抗生素、激素调节剂、生物制剂和手术方法在内的传统治疗反应不足。低剂量放射疗法已用于良性皮肤疾病，包括 HS；然而，关于其疗效的文献很少。在此，我们系统地回顾了放射疗法治疗 HS 患者的疗效的现有文献。
本系统评价对已发表文献的回顾报告了放射疗法治疗 HS 的患者人口统计学特征、治疗方案、疗效和不良反应。这些出版物的历史时间线突出了管理建议的变化、更标准化的结果测量指标的引入以及治疗选择的改进。放射疗法似乎是治疗抵抗性 HS 或手术候选者较差的患者的一种选择。然而，对于适当的候选者选择、剂量、疗效以及放射疗法的短期和长期效果的安全性，仍缺乏共识。
