Nacoti Mirco, Fazzi Francesco, Biroli Francesco, Zangari Rosalia, Barbui Tiziano, Kochanek Patrick M
Pediatric Intensive Care Unit, Department of Anesthesia and Intensive Care, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Fondazione per la Ricerca dell'Ospedale di Bergamo Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Front Pediatr. 2021 Jan 18;8:594425. doi: 10.3389/fped.2020.594425. eCollection 2020.
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children and adolescents. Survivors of severe TBI are more prone to functional deficits, resulting in poorer school performance, poor health-related quality of life (HRQoL), and increased risk of mental health problems. Critical gaps in knowledge of pathophysiological differences between children and adults concerning TBI outcomes, the paucity of pediatric trials and prognostic models and the uncertain extrapolation of adult data to pediatrics pose significant challenges and demand global efforts. Here, we explore the clinical and research unmet needs focusing on severe pediatric TBI to identify best practices in pathways of care and optimize both inpatient and outpatient management of children following TBI.
创伤性脑损伤（TBI）是儿童和青少年发病和死亡的主要原因。重度TBI幸存者更容易出现功能缺陷，导致学业成绩较差、健康相关生活质量（HRQoL）不佳以及心理健康问题风险增加。儿童和成人在TBI预后方面病理生理差异的知识存在重大空白，儿科试验和预后模型匮乏，以及将成人数据外推至儿科的不确定性，这些都构成了重大挑战，需要全球共同努力。在此，我们探讨针对重度小儿TBI的临床和研究未满足需求，以确定护理路径中的最佳实践，并优化TBI患儿的住院和门诊管理。
