Kim Y I, Calne R Y, Nagasue N
Department of Surgery, University of Cambridge, Addenbrooke's Hospital, England.
Surg Gynecol Obstet. 1988 Apr;166(4):317-22.
The effects of cyclosporin A (CyA) upon regeneration of the liver were studied in rats after partial hepatectomy. In group 1, a standard two-thirds hepatectomy was performed. In group 2, CyA, a dose of 10 milligrams per kilogram, was given orally one day prior to, on the day of the operation and 24 hours after hepatectomy. The liver weight restoration, histologic findings and mitotic activities of remnant livers and serum levels of aminotransferase, albumin, total bilirubin and creatinine values were examined from 24 hours to ten days after the operation. Treatment with CyA resulted in an increase of the mitotic activities of the hepatocytes, which were twice as high as those in the control group. This phenomenon coincided well with the regenerative rate of remnant livers, histologic factors, albumin synthesis and other biochemical parameters. Our results indicate that CyA has a stimulatory effect upon liver cell proliferation after partial hepatectomy in rats. The augmentative effect of CyA on liver regeneration is discussed.
在大鼠部分肝切除术后，研究了环孢素A（CyA）对肝脏再生的影响。第1组进行标准的三分之二肝切除术。第2组在手术前一天、手术当天及肝切除术后24小时，按每千克体重10毫克的剂量口服CyA。在术后24小时至10天期间，检测残余肝脏的肝重恢复情况、组织学表现、有丝分裂活性以及血清转氨酶、白蛋白、总胆红素和肌酐值水平。CyA治疗导致肝细胞有丝分裂活性增加，其活性是对照组的两倍。这一现象与残余肝脏的再生率、组织学因素、白蛋白合成及其他生化参数非常吻合。我们的结果表明，CyA对大鼠部分肝切除术后的肝细胞增殖具有刺激作用。文中讨论了CyA对肝脏再生的增强作用。
