Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
BMJ Case Rep. 2021 Feb 4;14(2):e236825. doi: 10.1136/bcr-2020-236825.
Acute cerebellar ataxia is a rare primary manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE). We report a case of a 22-year-old woman who presented with gait instability, behavioural changes and new-onset seizures. The tempo of disease progression was explained by an autoimmune cause, eventually fulfilling the criteria for systemic lupus erythematosus. The patient's neurological symptoms improved markedly following administration of steroids and immunomodulators. A review of literature on cerebellar ataxia in NPSLE and a summary of all reported cases to date are also presented.
急性小脑共济失调是神经精神性系统性红斑狼疮（NPSLE）的一种罕见首发表现。我们报告了一例 22 岁女性，其表现为步态不稳、行为改变和新发癫痫。疾病进展的速度由自身免疫原因解释，最终符合系统性红斑狼疮的标准。患者的神经系统症状在接受类固醇和免疫调节剂治疗后显著改善。本文还对 NPSLE 中小脑共济失调的文献进行了回顾，并对迄今为止所有报告的病例进行了总结。
