Department of Biological Sciences, Missouri University of Science and Technology, Rolla, Missouri, USA.
Institute of Biodiversity, Animal Health and Comparative Medicine, Graham Kerr Building, University of Glasgow, Glasgow, UK.
Bioessays. 2021 Apr;43(4):e2000165. doi: 10.1002/bies.202000165. Epub 2021 Feb 4.
It has been assumed that at the whole organismal level, the mitochondrial reactive oxygen species (ROS) production is proportional to the oxygen consumption. Recently, a number of researchers have challenged this assumption, based on the observation that the ROS production per unit oxygen consumed in the resting state of mitochondrial respiration is much higher than that in the active state. Here, we develop a simple model to investigate the validity of the assumption and the challenge of it. The model highlights the significance of the time budget that mitochondria operate in the different respiration states. The model suggests that under three physiologically possible conditions, the difference in ROS production per unit oxygen consumed between the respiration states does not upset the proportionality between the whole animal ROS production and oxygen consumption. The model also shows that mitochondrial uncoupling generally enhances the proportionality.
人们一直认为，在整个机体水平上，线粒体活性氧（ROS）的产生与耗氧量成正比。最近，一些研究人员根据观察到的结果对这一假设提出了质疑，即在静息状态下，线粒体呼吸每单位耗氧量产生的 ROS 比在活跃状态下要高得多。在这里，我们开发了一个简单的模型来研究该假设及其挑战的有效性。该模型强调了线粒体在不同呼吸状态下运行的时间预算的重要性。该模型表明，在三种生理上可能的条件下，呼吸状态下每单位耗氧量产生的 ROS 差异不会破坏整个动物 ROS 产生与耗氧量之间的比例关系。该模型还表明，线粒体解偶联通常会增强这种比例关系。
