Department of Dermatology, Al-Azhar University, Cairo, Egypt.
Department of Dermatology, National Research Centre, Cairo, Egypt.
J Cosmet Dermatol. 2021 Sep;20(9):2867-2873. doi: 10.1111/jocd.13976. Epub 2021 Feb 12.
Pumpkin (Cucurbita pepo L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance.
The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam.
Patients with FPHL were randomly assigned to pumpkin seed oil (n = 30; group A) or minoxidil 5% foam (n = 30; group B) for a period of 3 months. Patients were evaluated clinically and dermoscopically at baseline, at one and half months, and at the end of the 3-month study.
Among group A (pumpkin seed oil) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (30.5 ± 6.2%, 24.0 ± 4.02, P < .001, respectively) as well as in the vellus hairs (22.5 ± 4.9, 15.8 ± 2.2, P < .001, respectively). Upright regrowing hairs significantly increased from (0.13 ± 0.5) before treatment to (0.9 ± 1.0) after treatment (P < .001). In group B (minoxidil applying) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (31.5 ± 6.3%, 21.3 ± 2.2, P < .001, respectively) as well as in the vellus hairs (24.7 ± 6.4, 19.5 ± 5.4, P = .02, respectively). Conclusion Findings of the present trial provide evidence of a promising potential role of PSO in treating FPHL.
南瓜（Cucurbita pepo L.）是一种一年生攀援植物，其种子含有大量具有营养和药用重要性的油。
本研究旨在探讨南瓜籽油（PSO）治疗女性型脱发（FPHL）的临床疗效，并将其与 5%米诺地尔泡沫进行比较。
将 FPHL 患者随机分为南瓜籽油（n=30；A 组）或 5%米诺地尔泡沫（n=30；B 组）治疗组，治疗期为 3 个月。患者在基线、治疗 1.5 个月和 3 个月时进行临床和皮肤镜评估。
A 组（南瓜籽油）患者的毛发轴多样性在治疗前后有显著下降（30.5±6.2%，24.0±4.02%，P<.001），绒毛毛发也有显著下降（22.5±4.9%，15.8±2.2%，P<.001）。直立再生毛发显著增加，从治疗前的（0.13±0.5）增加到治疗后的（0.9±1.0）（P<.001）。B 组（米诺地尔应用）患者的毛发轴多样性在治疗前后有显著下降（31.5±6.3%，21.3±2.2%，P<.001），绒毛毛发也有显著下降（24.7±6.4%，19.5±5.4%，P=.02）。
本研究结果为 PSO 在治疗 FPHL 方面具有潜在的应用前景提供了证据。
