糖尿病肾病中的线粒体激酶 PINK1。
The Mitochondrial Kinase PINK1 in Diabetic Kidney Disease.
机构信息
Kolling Institute, Sydney Medical School, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, Australia.
出版信息
Int J Mol Sci. 2021 Feb 3;22(4):1525. doi: 10.3390/ijms22041525.
Mitochondria are critical organelles that play a key role in cellular metabolism, survival, and homeostasis. Mitochondrial dysfunction has been implicated in the pathogenesis of diabetic kidney disease. The function of mitochondria is critically regulated by several mitochondrial protein kinases, including the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1). The focus of PINK1 research has been centered on neuronal diseases. Recent studies have revealed a close link between PINK1 and many other diseases including kidney diseases. This review will provide a concise summary of PINK1 and its regulation of mitochondrial function in health and disease. The physiological role of PINK1 in the major cells involved in diabetic kidney disease including proximal tubular cells and podocytes will also be summarized. Collectively, these studies suggested that targeting PINK1 may offer a promising alternative for the treatment of diabetic kidney disease.
线粒体是细胞代谢、生存和内稳态的关键细胞器。线粒体功能障碍与糖尿病肾病的发病机制有关。几种线粒体蛋白激酶，包括磷酸酶和张力蛋白同源物（PTEN）诱导的激酶 1（PINK1），对线粒体的功能具有关键的调节作用。PINK1 的研究重点一直集中在神经疾病上。最近的研究揭示了 PINK1 与许多其他疾病（包括肾脏疾病）之间的密切联系。这篇综述将简要总结 PINK1 及其在健康和疾病中对线粒体功能的调节。还将总结 PINK1 在包括近端肾小管细胞和足细胞在内的参与糖尿病肾病的主要细胞中的生理作用。总的来说，这些研究表明，靶向 PINK1 可能为治疗糖尿病肾病提供一种有前途的替代方法。
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