穿山甲冠状病毒刺突糖蛋白的结构和结合特性提示 SARS-CoV-2 的进化。
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2.
机构信息
Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
出版信息
Nat Commun. 2021 Feb 5;12(1):837. doi: 10.1038/s41467-021-21006-9.
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.
蝙蝠和穿山甲冠状病毒被认为与新冠病毒 SARS-CoV-2 的起源和进化有关。我们发现与 SARS-CoV-2 密切相关的广东穿山甲冠状病毒的刺突蛋白能够与人及穿山甲 ACE2 受体强力结合。我们还报道了一种穿山甲冠状病毒刺突蛋白的冷冻电镜结构，并展示了它呈现完全闭合构象，除了受体结合结构域之外，它与蝙蝠冠状病毒 RaTG13 的刺突蛋白更相似，而不是与 SARS-CoV-2 的刺突蛋白相似。
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