Bono Federica, Mutti Veronica, Piovani Giovanna, Minelli Alessandra, Mingardi Jessica, Guglielmi Adele, Missale Cristina, Gennarelli Massimo, Fiorentini Chiara, Barbon Alessandro
Division of Pharmacology, Department of, Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Stem Cell Res. 2021 Mar;51:102216. doi: 10.1016/j.scr.2021.102216. Epub 2021 Jan 29.
Peripheral blood mononuclear cells (PBMCs) derived from a healthy 40-year-old female were successfully transformed into induced pluripotent stem cells (iPSCs) by using the integration-free CytoTune-iPS Sendai Reprogramming method. The resulting iPSCs line exhibits a normal karyotype, expresses stemness markers and displays the differentiation capacity into the three germ layers. This human iPSCs line can be used as healthy control in disease modelling studies.
通过使用无整合的CytoTune-iPS仙台重编程方法，成功地将来自一名40岁健康女性的外周血单个核细胞（PBMCs）转化为诱导多能干细胞（iPSCs）。所得的iPSCs系具有正常的核型，表达干性标志物，并表现出向三个胚层分化的能力。该人类iPSCs系可用于疾病建模研究中的健康对照。
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