Departamento de Química Fundamental, CCEN, Universidade Federal de Pernambuco, Av. Jornalista Anibal Fernandes, S/N, 50740-560, Recife, Brazil.
Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, Brazil.
Top Curr Chem (Cham). 2021 Feb 7;379(2):12. doi: 10.1007/s41061-021-00325-x.
The development of multimodal nanoprobes has been growing in recent years. Among these novel nanostructures are bimodal systems based on quantum dots (QDs) and low molecular weight Gd chelates, prepared for magnetic resonance imaging (MRI) and optical analyses. MRI is a technique used worldwide that provides anatomic resolution and allows distinguishing of physiological differences at tissue and organ level. On the other hand, optical techniques are very sensitive and allow events to be followed at the cellular or molecular level. Thus, the association of these two techniques has the potential to achieve a more complete comprehension of biological processes. In this review, we present state-of-the-art research concerning the development of potential multimodal optical/paramagnetic nanoprobes based on Gd chelates and QDs, highlighting their preparation strategies and overall properties.
近年来，多模态纳米探针的发展日益增长。在这些新型纳米结构中，基于量子点 (QD) 和低分子量 Gd 螯合物的双模态系统备受关注，可用于磁共振成像 (MRI) 和光学分析。MRI 是一种在全球范围内使用的技术，提供解剖分辨率，并允许区分组织和器官水平的生理差异。另一方面，光学技术非常敏感，可用于在细胞或分子水平上跟踪事件。因此，这两种技术的结合有可能实现对生物过程的更全面理解。在这篇综述中，我们介绍了基于 Gd 螯合物和 QD 的潜在多模态光学/顺磁纳米探针的最新研究进展，重点介绍了它们的制备策略和整体性能。
