Cao Hui, Hou Chao, Huang Saiping, Zhou Xiafeng, Yang Jun, Xu Jia Bin, Cao Xiaoyun, Li Zhenguang, Zhang Wei, Zhang Mei, Liu Xuejun, Zhou Xuhui
Department of Psychiatry, The Second People's Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, China.
Department of Psychiatry, Mental Hospital of Jiangxi Province, Nanchang, China.
Front Psychiatry. 2021 Jan 21;11:598835. doi: 10.3389/fpsyt.2020.598835. eCollection 2020.
Recently, the cognitive impairment of patients with alcohol dependence has attracted more and more attention. The combination of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and event-related potentials (ERPs) for evaluating the degree of cognitive impairment in patients with alcohol dependence has not undergone enough in-depth investigation. Sixty patients with alcohol dependence were selected as alcohol-dependence group, whereas 40 healthy volunteers served as a normal control group. The original scores of the RBANS sub-items, the incubation period, and volatility of ERPs between the two groups were compared, and the correlation among the above indicators in the alcohol-dependence group was further analyzed. The RBANS test showed that the original scores of speech function, attention function, delayed memory, and immediate attention in the alcohol-dependence group were significantly lower than those in the normal control group. Compared with the normal control group, the latencies of P200 and P300 in the alcohol-dependence group were significantly prolonged, and the amplitude of P200 and P300 was significantly reduced. Correlation analysis between RBANS and ERPs in alcohol-dependence group showed that immediate attention score was positively correlated with P300 and P200 amplitude, visual breadth score was positively correlated with P200 latency, and attention function score was negatively correlated with P300 latency. As RBANS scale was highly correlated with the results of ERPs, the combined use of these two scales may serve as an objective basis for early diagnosis of cognitive impairment in patients with alcohol dependence.
近年来，酒精依赖患者的认知障碍越来越受到关注。用于评估酒精依赖患者认知障碍程度的神经心理状态重复成套测验（RBANS）与事件相关电位（ERP）的联合应用尚未得到足够深入的研究。选取60例酒精依赖患者作为酒精依赖组，40例健康志愿者作为正常对照组。比较两组RBANS子项目的原始得分、ERP的潜伏期和波幅，并进一步分析酒精依赖组上述指标之间的相关性。RBANS测试显示，酒精依赖组的言语功能、注意力功能、延迟记忆和即时注意力的原始得分显著低于正常对照组。与正常对照组相比，酒精依赖组P200和P300的潜伏期显著延长，P200和P300的波幅显著降低。酒精依赖组RBANS与ERP的相关性分析显示，即时注意力得分与P300和P200波幅呈正相关，视觉广度得分与P200潜伏期呈正相关，注意力功能得分与P300潜伏期呈负相关。由于RBANS量表与ERP结果高度相关，这两种量表的联合使用可为酒精依赖患者认知障碍的早期诊断提供客观依据。
