Evaluation of the anti-inflammatory and antioxidant effects of the microalgae in streptozotocin-induced diabetic rats.

PURPOSE

This study aims to evaluate the anti-inflammatory and antioxidant effects of on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats.

METHODS

Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined.

RESULTS

It was notice that levels of glucose, glycated hemoglobin (HbA), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly ( < 0.05) in diabetic rats. Moreover, undesirable alterations of oxidative stress markers of tissue and mitochondria isolated from the liver were noted in these rats. supplementation was shown effective in lowering the levels of glucose, HbA and improving the renal and hepatic function and also in attenuating the oxidative stress and inflammation in diabetic rats.

CONCLUSION

possesses antioxidant properties that might have beneficial effect in treatment of diabetes.