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本文引用的文献

1
Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends.2 型糖尿病的流行病学——全球疾病负担和预测趋势。
J Epidemiol Glob Health. 2020 Mar;10(1):107-111. doi: 10.2991/jegh.k.191028.001.
2
Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats.眼点拟微球藻对链脲佐菌素诱导的糖尿病大鼠的降血糖和降血脂活性
Biomol Concepts. 2019 Mar 11;10(1):37-43. doi: 10.1515/bmc-2019-0004.
3
Beneficial effects of Spirogyra Neglecta Extract on antioxidant and anti-inflammatory factors in streptozotocin-induced diabetic rats.纤细刚毛藻提取物对链脲佐菌素诱导的糖尿病大鼠抗氧化和抗炎因子的有益作用。
Biomol Concepts. 2018 Dec 31;9(1):184-189. doi: 10.1515/bmc-2018-0015.
4
Chemically-Induced Production of Anti-Inflammatory Molecules in Microalgae.微藻中诱导抗炎分子的化学合成。
Mar Drugs. 2018 Nov 30;16(12):478. doi: 10.3390/md16120478.
5
Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats.马齿苋对链脲佐菌素诱导的糖尿病大鼠氧化应激和炎症的减轻作用
J Evid Based Complementary Altern Med. 2017 Oct;22(4):562-566. doi: 10.1177/2156587217692491. Epub 2017 Feb 21.
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Microalgae as healthy ingredients for functional food: a review.微藻作为功能性食品的健康成分：综述。
Food Funct. 2017 Aug 1;8(8):2672-2685. doi: 10.1039/c7fo00409e. Epub 2017 Jul 6.
7
Effect of Spirulina platensis ingestion on the abnormal biochemical and oxidative stress parameters in the pancreas and liver of alloxan-induced diabetic rats.钝顶螺旋藻摄入对四氧嘧啶诱导的糖尿病大鼠胰腺和肝脏中异常生化及氧化应激参数的影响。
Pharm Biol. 2017 Dec;55(1):1304-1312. doi: 10.1080/13880209.2017.1300820.
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The role of mitochondria in metabolism and cell death.线粒体在新陈代谢和细胞死亡中的作用。
Biochem Biophys Res Commun. 2017 Jan 15;482(3):426-431. doi: 10.1016/j.bbrc.2016.11.088. Epub 2017 Feb 3.
9
Marine Organisms with Anti-Diabetes Properties.具有抗糖尿病特性的海洋生物。
Mar Drugs. 2016 Dec 1;14(12):220. doi: 10.3390/md14120220.
10
Targeting metabolic disorders by natural products.利用天然产物治疗代谢紊乱
J Diabetes Metab Disord. 2015 Jul 8;14:57. doi: 10.1186/s40200-015-0184-8. eCollection 2015.

微藻对链脲佐菌素诱导的糖尿病大鼠的抗炎和抗氧化作用评估。

Evaluation of the anti-inflammatory and antioxidant effects of the microalgae in streptozotocin-induced diabetic rats.

作者信息

Nacer Wassila, Baba Ahmed Fatima Zohra, Merzouk Hafida, Benyagoub Ouahiba, Bouanane Samira

机构信息

Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, 13000 Tlemcen, Algeria.

出版信息

J Diabetes Metab Disord. 2020 Nov 2;19(2):1483-1490. doi: 10.1007/s40200-020-00681-3. eCollection 2020 Dec.

DOI:10.1007/s40200-020-00681-3
PMID:33553035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7843831/
Abstract

PURPOSE

This study aims to evaluate the anti-inflammatory and antioxidant effects of on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats.

METHODS

Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined.

RESULTS

It was notice that levels of glucose, glycated hemoglobin (HbA), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly ( < 0.05) in diabetic rats. Moreover, undesirable alterations of oxidative stress markers of tissue and mitochondria isolated from the liver were noted in these rats. supplementation was shown effective in lowering the levels of glucose, HbA and improving the renal and hepatic function and also in attenuating the oxidative stress and inflammation in diabetic rats.

CONCLUSION

possesses antioxidant properties that might have beneficial effect in treatment of diabetes.

摘要

目的

本研究旨在评估[具体物质未给出]对链脲佐菌素（STZ）诱导的Wistar大鼠糖尿病的抗炎和抗氧化作用。

方法

通过单次腹腔注射STZ（45毫克/千克）诱导雄性Wistar大鼠患糖尿病。雄性大鼠以补充或不补充[具体物质未给出]（10%）的对照饮食喂养2个月。实验结束时，测定肝脏和胰腺组织以及从大鼠肝脏分离的线粒体中的生化参数和氧化/抗氧化标志物。

结果

注意到糖尿病大鼠的血糖、糖化血红蛋白（HbA）、血脂谱、肾功能和肝酶水平以及炎症反应标志物白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）显著升高（<0.05）。此外，在这些大鼠中还观察到从肝脏分离的组织和线粒体的氧化应激标志物的不良改变。补充[具体物质未给出]被证明可有效降低血糖、HbA水平，改善肾和肝功能，并减轻糖尿病大鼠的氧化应激和炎症。

结论

[具体物质未给出]具有抗氧化特性，可能对糖尿病治疗有有益作用。