双光子激发肽纳米药物用于精准光动力治疗。
Two-photon excited peptide nanodrugs for precise photodynamic therapy.
机构信息
School of Public Health, Shandong University, Jinan, Shandong, China.
出版信息
Chem Commun (Camb). 2021 Mar 4;57(18):2245-2248. doi: 10.1039/d0cc08219h. Epub 2021 Feb 8.
PMID:33554229
Abstract
A novel peptide nanodrug composed of three functional motifs, bis(pyrene), FFVLK and CREKA, was used as a two-photon excited photosensitizer for precise photodynamic therapy (PDT). The system presented excellent two-photon imaging ability, tumor target effect and high reactive oxygen species productivity for improving treatment precision and efficiency in PDT.
摘要
一种新型的由三个功能基序（双芘、FFVLK 和 CREKA）组成的肽纳米药物被用作双光子激发的光敏剂，用于精确的光动力疗法（PDT）。该系统具有优异的双光子成像能力、肿瘤靶向效果和高活性氧产生能力，可提高 PDT 的治疗精度和效率。
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