Teggi Roberto, Battista Rosa Alessia, Di Berardino Federica, Familiari Marco, Cangiano Iacopo, Gatti Omar, Bussi Mario
Department of Otolaryngology Head & Neck Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vita-Salute San Raffaele University, Milan, Italy.
Acta Otorhinolaryngol Ital. 2020 Dec;40(6):444-449. doi: 10.14639/0392-100X-N0776.
The purpose of this study was to assess vestibular findings and clinical history in a large cohort of patients affected by Ménière's disease.
We retrospectively analysed 511 adult patients fulfilling criteria for definite unilateral Ménière's disease according to Barany Society. Thorough clinical history, audiometric exam, central nervous system MRI, quantification of serum autoantibodies and complete vestibular function test were performed.
Mean age at clinical record was 55.4 years, while age at onset of the first vertigo attack was 47.4 ± 14.3 years. Ménière's disease overlapped with migraine in 43.4% of patients. In 31.7% of cases, positivity was found for at least one autoantibody. Forty-nine patients (9.6%) had family history for Ménière's disease. Bedside examination resulted in 14.7% positivity for video head impulse test, 58.9% for skull vibration-induced nystagmus, 38.7% for the positional test and 23.1% for the post head shaking test. Complete negative examination was reported in 115 cases.
Ménière's disease was seen to present a characteristic phenotypic pattern in our cohort, confirming the crucial role of thorough anamnesis and bedside examination in diagnosis.
本研究旨在评估大量梅尼埃病患者的前庭检查结果及临床病史。
我们回顾性分析了511例符合巴拉尼协会（Barany Society）明确单侧梅尼埃病标准的成年患者。进行了全面的临床病史、听力检查、中枢神经系统磁共振成像、血清自身抗体定量及完整的前庭功能测试。
临床记录时的平均年龄为55.4岁，首次眩晕发作时的年龄为47.4±14.3岁。43.4%的患者梅尼埃病与偏头痛重叠。在31.7%的病例中，至少一种自身抗体呈阳性。49例患者（9.6%）有梅尼埃病家族史。床边检查中，视频头脉冲试验阳性率为14.7%，头颅振动诱发眼震阳性率为58.9%，位置试验阳性率为38.7%，摇头后试验阳性率为23.1%。115例报告检查完全阴性。
在我们的队列中，梅尼埃病呈现出特征性的表型模式，证实了全面问诊和床边检查在诊断中的关键作用。
