Rao D S, Grogan J B
Transplantation. 1977 Nov;24(5):377-81. doi: 10.1097/00007890-197711000-00010.
Allogeneic tissue implantation to the anterior chamber of the eye indicated that the host response varies with the size of the implant. Small implants (0.5 mm2) placed in the anterior chamber prolonged the survival of subsequent orthotopic skin allografts across major histocompatibility differences. In contrast, large implants (2.0 mm2) accelerated the rejection of specific skin grafts. The observed delay in graft rejection of small implant-bearing rats was specific to the implant donor, since the third-party unrelated skin grafts on these animals showed neither increase nor decrease in survival times.
将同种异体组织植入眼前房表明，宿主反应随植入物大小而异。置于前房的小植入物（0.5平方毫米）延长了随后跨越主要组织相容性差异的原位皮肤同种异体移植的存活时间。相反，大植入物（2.0平方毫米）加速了特定皮肤移植物的排斥反应。观察到的带有小植入物的大鼠移植物排斥延迟对植入物供体具有特异性，因为这些动物上的第三方无关皮肤移植物的存活时间既没有增加也没有减少。
