Spizzirri Umile Gianfranco, Aiello Francesca, Carullo Gabriele, Facente Anastasia, Restuccia Donatella
Department of Pharmacy, Health and Nutritional Sciences Department of Excellence 2018-2022, University of Calabria, Edificio Polifunzionale, 87036 Rende, Italy.
Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Pharmaceutics. 2021 Feb 6;13(2):230. doi: 10.3390/pharmaceutics13020230.
Site-Specific release of active molecules with antimicrobial activity spurred the interest in the development of innovative polymeric nanocarriers. In the preparation of polymeric devices, nanotechnologies usually overcome the inconvenience frequently related to other synthetic strategies. High performing nanocarriers were synthesized using a wide range of starting polymer structures, with tailored features and great chemical versatility. Over the last decade, many antimicrobial substances originating from plants, herbs, and agro-food waste by-products were deeply investigated, significantly catching the interest of the scientific community. In this review, the most innovative strategies to synthesize nanodevices able to release antimicrobial natural extracts were discussed. In this regard, the properties and structure of the starting polymers, either synthetic or natural, as well as the antimicrobial activity of the biomolecules were deeply investigated, outlining the right combination able to inhibit pathogens in specific biological compartments.
具有抗菌活性的活性分子的位点特异性释放激发了人们对开发创新型聚合物纳米载体的兴趣。在聚合物器件的制备中，纳米技术通常克服了与其他合成策略相关的不便之处。使用多种起始聚合物结构合成了高性能纳米载体，这些结构具有定制的特性和很强的化学通用性。在过去十年中，对许多源自植物、草药和农业食品废弃物副产品的抗菌物质进行了深入研究，极大地引起了科学界的兴趣。在这篇综述中，讨论了合成能够释放抗菌天然提取物的纳米器件的最具创新性的策略。在这方面，深入研究了起始聚合物（无论是合成的还是天然的）的性质和结构，以及生物分子的抗菌活性，概述了能够在特定生物隔室中抑制病原体的正确组合。
