非离子型嵌段聚合物表面活性剂可增强肺炎球菌六糖-蛋白疫苗的免疫原性。
Nonionic block polymer surfactants enhance immunogenicity of pneumococcal hexasaccharide-protein vaccines.
作者信息
Zigterman G J, Snippe H, Jansze M, Ernste E B, De Reuver M J, Willers J M
机构信息
Department of Immunology, State University of Utrecht, The Netherlands.
出版信息
Infect Immun. 1988 May;56(5):1391-3. doi: 10.1128/iai.56.5.1391-1393.1988.
Abstract
Incorporated in oil-in-water emulsions, nonionic block polymer surfactants change the kinetics of generated antibody responses against pneumococcal hexasaccharide-protein conjugates: prolonged immunoglobulin M and immunoglobulin G responses are realized. Nonionic block polymer surfactants favor the immunogenicity of hexasaccharide-protein conjugates in young mice in such a way that a single injection yields long-lasting protection.
摘要
非离子型嵌段聚合物表面活性剂被掺入水包油乳液中，可改变针对肺炎球菌六糖-蛋白质偶联物产生抗体反应的动力学：实现了免疫球蛋白M和免疫球蛋白G反应的延长。非离子型嵌段聚合物表面活性剂以一种单次注射就能产生持久保护的方式，有利于六糖-蛋白质偶联物在幼鼠中的免疫原性。
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本文引用的文献
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