通过酶联免疫吸附测定法检测到的针对肺炎球菌多糖的免疫球蛋白G和M抗体。
Immunoglobulin G and M antibodies to pneumococcal polysaccharides detected by enzyme-linked immunosorbent assay.
作者信息
Barrett D J, Ammann A J, Stenmark S, Wara D W
出版信息
Infect Immun. 1980 Feb;27(2):411-7. doi: 10.1128/iai.27.2.411-417.1980.
Abstract
An enzyme-linked immunosorbent assay has been developed to detect serum immunoglobulin G and M antibodies against pneumococcal polysaccharide antigens. Parameters affecting the specificity and sensitivity of the assay are described. A vigorous antibody response involving both the immunoglobulin G and M classes was demonstrated after pneumococcal polysaccharide immunization in normal adults. Studies with this enzyme-linked immunosorbent assay technique will allow further understanding of the biology of the primary and secondary immune response to Streptococcus pneumoniae in normals as well as in those persons most susceptible to infection with that organism.
摘要
已开发出一种酶联免疫吸附测定法来检测针对肺炎球菌多糖抗原的血清免疫球蛋白G和M抗体。描述了影响该测定法特异性和敏感性的参数。在正常成年人中进行肺炎球菌多糖免疫后，证实了涉及免疫球蛋白G和M类别的强烈抗体反应。使用这种酶联免疫吸附测定技术进行的研究将有助于进一步了解正常人和最易感染该病原体的人群对肺炎链球菌的初次和二次免疫反应的生物学特性。
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