May Bruna Miers, Pimentel Mauricio, Zimerman Leandro Ioschpe, Rohde Luis Eduardo
Universidade Federal do Rio Grande do Sul - Programa de Pós-Graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares , Porto Alegre , RS - Brasil.
Hospital de Clinicas de Porto Alegre , Porto Alegre , RS - Brasil.
Arq Bras Cardiol. 2021 Mar;116(3):494-500. doi: 10.36660/abc.20200426.
In the last years, several diagnostic and prognostic biomarkers have been studied in cardiovascular disease. Growth differentiation factor-15 (GDF-15), a cytokine belonging to the transforming growth factor- (TGF-) family, is highly up-regulated in stress and inflammatory conditions and has been correlated to myocardial injury and pressure cardiac overload in animal models. This new biomarker has been positively correlated with increased risk of cardiovascular events in population studies and shown an independent predictor of mortality in patients with coronary artery disease and heart failure. This review aimed to summarize the current evidence on the diagnostic and prognostic value of GDF-15 in different settings in cardiology.
在过去几年中，人们对心血管疾病的多种诊断和预后生物标志物进行了研究。生长分化因子-15（GDF-15）是一种属于转化生长因子-（TGF-）家族的细胞因子，在应激和炎症条件下高度上调，并且在动物模型中与心肌损伤和心脏压力过载相关。在人群研究中，这种新的生物标志物与心血管事件风险增加呈正相关，并且在冠心病和心力衰竭患者中是死亡率的独立预测指标。本综述旨在总结目前关于GDF-15在心脏病学不同情况下的诊断和预后价值的证据。
