Pratt Stephen J P, Hernández-Ochoa Erick, Martin Stuart S
Program in Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD USA.
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD USA.
Biophys Rev. 2020 Dec 18;12(6):1343-1359. doi: 10.1007/s12551-020-00771-9. eCollection 2020 Dec.
Calcium is a versatile element that participates in cell signaling for a wide range of cell processes such as death, cell cycle, division, migration, invasion, metabolism, differentiation, autophagy, transcription, and others. Specificity of calcium in each of these processes is achieved through modulation of intracellular calcium concentrations by changing the characteristics (amplitude/frequency modulation) or location (spatial modulation) of the signal. Breast cancer utilizes calcium signaling as an advantage for survival and progression. This review integrates evidence showing that increases in expression of calcium channels, GPCRs, pumps, effectors, and enzymes, as well as resulting intracellular calcium signals, lead to high calcium and/or an elevated calcium- mobilizing capacity necessary for malignant functions such as migratory, invasive, proliferative, tumorigenic, or metastatic capacities.
钙是一种多功能元素，参与多种细胞过程的细胞信号传导，如细胞死亡、细胞周期、分裂、迁移、侵袭、代谢、分化、自噬、转录等。通过改变信号的特征（幅度/频率调制）或位置（空间调制）来调节细胞内钙浓度，从而实现钙在这些过程中的特异性作用。乳腺癌利用钙信号作为生存和进展的优势。本综述整合了相关证据，表明钙通道、G蛋白偶联受体、泵、效应器和酶的表达增加，以及由此产生的细胞内钙信号，会导致高钙水平和/或提高钙动员能力，这对于迁移、侵袭、增殖、致瘤或转移等恶性功能是必需的。
