Department of Inflammology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Cancer Sci. 2021 Jul;112(7):2578-2591. doi: 10.1111/cas.14848. Epub 2021 May 1.
The signal-transducing innate receptors represent classes of pattern recognition receptors (PRRs) that play crucial roles in the first line of the host defense against infections by the recognition of pathogen-derived molecules. Because of their poorly discriminative nature compared with antigen receptors of the adaptive immune system, they also recognize endogenous molecules and evoke immune responses without infection, resulting in the regulation of tumor immunity. Therefore, PRRs may be promising targets for effective cancer immunotherapy, either by activating or inhibiting them. Here, we summarize our current knowledge of signal-transducing PRRs in the regulation of tumor immunity.
信号转导固有受体代表了一类模式识别受体 (PRRs)，它们在宿主防御感染的第一线中发挥着至关重要的作用，通过识别病原体衍生的分子来实现。与适应性免疫系统的抗原受体相比，由于它们的区分能力较差，因此它们也可以识别内源性分子，并在没有感染的情况下引发免疫反应，从而调节肿瘤免疫。因此，PRRs 可能是有效癌症免疫治疗的有前途的靶点，无论是通过激活还是抑制它们。在这里，我们总结了我们目前对信号转导 PRRs 在肿瘤免疫调节中的认识。
