Department of Medical Affairs, Clinical Research, Mead Johnson Nutrition, Evansville, IN 47721, USA.
Department of Biotechnology, Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Agustin Escardino 7, 46980 Paterna, Valencia, Spain.
Nutrients. 2021 Jan 30;13(2):464. doi: 10.3390/nu13020464.
The trend toward using phytonutrients and/or nutraceuticals (P/Ns) with the aim of impacting immune health has increased in recent years. The main reason is that properties of P/Ns are associated with possible immunomodulating effects in the prevention and complementary treatment of viral diseases, including COVID-19 and other respiratory infections. In the present review, we assess the scientific plausibility of specific P/Ns for this purpose of preventative and therapeutic interventions against COVID-19, with an emphasis on safety, validity, and evidence of efficacy against other viruses. Five potential candidates have been identified after reviewing available studies (in silico, in vitro, and in vivo) in which certain flavonoids have demonstrated a potential for use as adjuvant therapeutic agents against viral infections, including COVID-19. As these are often better tolerated than pharmacological treatments, their use could be more widely considered if additional detailed studies can validate the existing evidence.
近年来，人们越来越倾向于使用植物营养素和/或营养保健品（P/Ns）来影响免疫健康。主要原因是 P/Ns 的特性与预防和补充治疗病毒性疾病（包括 COVID-19 和其他呼吸道感染）的可能免疫调节作用有关。在本综述中，我们评估了特定 P/Ns 用于预防和治疗 COVID-19 的科学合理性，重点关注安全性、有效性和对其他病毒的疗效证据。在审查了针对病毒感染（包括 COVID-19）具有潜在用途的某些黄酮类化合物的现有研究（包括基于计算机的研究、体外研究和体内研究）后，确定了五个有潜力的候选药物。由于这些药物通常比药物治疗更能耐受，因此如果进一步的详细研究能够验证现有证据，它们的使用可能会得到更广泛的考虑。
