El Hachlafi Naoufal, Chebat Abderrahim, Fikri-Benbrahim Kawtar
Microbial Biotechnology and Bioactive Molecules Laboratory, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, P.O. Box 2202, Imouzzer Road, Fez, Morocco.
Moroccan Anti Poison and Pharmacovigilance Center, P.O. Box 6671, Rabat, Morocco.
Evid Based Complement Alternat Med. 2021 Jan 27;2021:6673838. doi: 10.1155/2021/6673838. eCollection 2021.
Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as "Azkouni" or "Zaitra." It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on . Chemical characterization of essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of into scientific-based information are strongly required. Additional pharmacological studies are recommended to validate the results of the studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of .
科斯属植物（唇形科）是一种摩洛哥药用植物，当地称为“Azkouni”或“Zaitra”。它在传统医学中被广泛用于治疗各种疾病，包括高血压、糖尿病、感冒、发烧、皮肤病和循环系统疾病、免疫问题、支气管炎、疼痛、清热、咽炎、咳嗽和流感。本综述旨在批判性地总结关于该植物的民族药理学用途、化学概况和药理学研究的文献，以便为进一步研究提供数据支持和科学证据。使用Scopus、PubMed、Web of Science、SciFinder、ScienceDirect、Google Scholar和Medline等电子数据库收集有关该植物的数据。对该植物精油（EOs）和提取物的化学表征共鉴定出139种生物活性化合物，主要属于萜类、酚酸类和黄酮类。该植物尤其是其精油表现出多种生物活性，如抗菌、抗真菌、抗炎、抗氧化、抗糖尿病、抗癌、抗寄生虫和降血脂活性。鉴于这些发现，强烈需要进一步研究将该植物的传统应用转化为基于科学的信息。建议进行更多的该植物药理学研究以验证研究结果。此外，应该对该植物及其生物活性化合物对分子靶点的药理作用机制进行全面的临床前和临床试验。最后，必须更加关注毒理学评估和药代动力学研究，以确保该植物的安全性和有效性。
