Nazareth, Azrieli Faculty of Medicine, Department of Medicine C and Rheumatology Unit, Laniado Hospital, Netanya, and Rheumatology Clinic Nazareth Hospital, Bar-Ilan University, Safed, Israel.
Faculty of Dental Medicine, Biofilm Research Laboratory, Hebrew University-Hadassah, Jerusalem, Israel.
PLoS One. 2021 Feb 12;16(2):e0247044. doi: 10.1371/journal.pone.0247044. eCollection 2021.
To evaluate the effect of medical cannabis consumption on oral flora and saliva.
A clinical prospective study, at the rheumatology clinic of the Nazareth Hospital in Nazareth, recruiting consecutively patients approved for medical cannabis, evaluating their saliva flow, pH and microbial load of Streptococcus mutans and Lactobacillus, prior to and under medical cannabis treatment.
Patients recently licensed for medical cannabis treatment, were recruited just prior to starting medical cannabis consumption (week 0), 1 and 4 weeks later, patients provided 5-minute time saliva samples, which were measured for their volume and pH, and cultured on a special microbial kit, evaluating the growth of Streptococcus mutans and Lactobacillus.
Out of 16 patients enrolled, 14 were female and had fibromyalgia. The mean age of the patients was 52.8±12.9 years. The mean saliva flow at week 0, week 1 and week 4 were 5.38±3.36 ml/5-minutes, 6 (p = 0.769) and 5.45 (p = 0.391), respectively, and for saliva pH were 6.28, 5.94 (p = 0.51) and 5.5 (p = 0.07) respectively also. The mean Streptococcus mutans growth score at weeks 0, 1 and 4 was1.8±0.75, 1.6±0.83 (p = 0.234), and 2.4±0.84 (p = 0.058), respectively. The mean Lactobacilli growth score at weeks 0, 1 and 4 was 2.59±0.88, 3.1±0.69 (p = 0.033) and 3.3±0.67 (p = 0.025), respectively.
The results of this study show that medical cannabis consumption has no significant effect on saliva volume or pH, but it may be associated with changes in salivary levels of oral microbes such as Streptococcus mutans and Lactobacilli.
评估医用大麻消费对口腔菌群和唾液的影响。
在拿撒勒医院的风湿病诊所进行的一项临床前瞻性研究，连续招募已批准使用医用大麻的患者，在开始使用医用大麻之前（第 0 周）以及使用后 1 周和 4 周，评估他们的唾液流量、pH 值以及变形链球菌和乳杆菌的微生物负荷。
招募最近获得医用大麻治疗许可的患者，在开始使用医用大麻之前（第 0 周）、1 周和 4 周后，患者提供 5 分钟的唾液样本，测量其体积和 pH 值，并在特殊的微生物试剂盒上培养，评估变形链球菌和乳杆菌的生长情况。
16 名入组患者中，14 名女性，患有纤维肌痛。患者的平均年龄为 52.8±12.9 岁。第 0 周、第 1 周和第 4 周的平均唾液流量分别为 5.38±3.36ml/5min、6（p=0.769）和 5.45（p=0.391），而唾液 pH 值分别为 6.28、5.94（p=0.51）和 5.5（p=0.07）。第 0 周、第 1 周和第 4 周的变形链球菌生长评分分别为 1.8±0.75、1.6±0.83（p=0.234）和 2.4±0.84（p=0.058）。第 0 周、第 1 周和第 4 周的乳杆菌生长评分分别为 2.59±0.88、3.1±0.69（p=0.033）和 3.3±0.67（p=0.025）。
本研究结果表明，医用大麻的使用对唾液量或 pH 值没有显著影响，但可能与变形链球菌和乳杆菌等口腔微生物的唾液水平变化有关。
