Subramanian K S
Environmental Health Directorate, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario.
Sci Total Environ. 1988 Apr;71(1):125-30. doi: 10.1016/0048-9697(88)90306-3.
An international co-operative blood-Pb interlaboratory study and a Canadian co-operative blood-Pb interlaboratory study were conducted using freeze-dried bovine blood samples with different endogenous Pb levels. The samples were prepared from whole blood of a nonexposed cow and another fed with a single dose of lead acetate. The mean values computed for the two samples analyzed by 25 international participants from 13 countries were 55 and 250 micrograms Pb l-1, respectively. These results showed a positive bias of 10% for the low level and 9% for the high Pb level with respect to the reference values obtained by isotope dilution mass spectrometry. In the case of the Canadian interlaboratory survey the mean values computed for the two samples analyzed by the 12 participants were 40 and 229 micrograms Pb l-1, respectively. These results showed a negative bias of 20 and 0.4% in relation to the target values of 50 and 230 micrograms Pb l-1, respectively. Despite such a bias, the data, on the whole, were of acceptable precision and accuracy when compared with previous interlaboratory blood-Pb surveys.
开展了一项国际血液铅含量实验室间合作研究以及一项加拿大血液铅含量实验室间合作研究，使用了具有不同内源性铅含量的冻干牛血样本。这些样本由一头未接触铅的奶牛的全血以及另一头单次喂食醋酸铅的奶牛的全血制备而成。来自13个国家的25名国际参与者对这两个样本进行分析后计算出的平均值分别为55微克铅/升和250微克铅/升。相对于通过同位素稀释质谱法获得的参考值，这些结果表明低水平铅含量存在10%的正偏差，高水平铅含量存在9%的正偏差。在加拿大的实验室间调查中，12名参与者对这两个样本进行分析后计算出的平均值分别为40微克铅/升和229微克铅/升。这些结果相对于50微克铅/升和230微克铅/升的目标值分别显示出20%和0.4%的负偏差。尽管存在这种偏差，但与之前的血液铅含量实验室间调查相比，总体数据的精密度和准确度是可以接受的。
