糖尿病酮症酸中毒、高甘油三酯血症及急性胰腺炎合并非免疫性溶血性贫血所致腹痛
Diabetic Ketoacidosis, Hypertriglyceridemia and Abdominal Pain due to Acute Pancreatitis Complicated by Non-immune Haemolytic Anaemia.
作者信息
Joustra Monica L, Raidt Janneke J, Droog Florens, Veneman Thiemo F
机构信息
Department of Internal Medicine, Ziekenhuisgroep Twente (Hospital Group Twente), Almelo, The Netherlands.
Department of Intensive Care Medicine, Ziekenhuisgroep Twente (Hospital Group Twente), Almelo, The Netherlands.
出版信息
Eur J Case Rep Intern Med. 2020 Dec 9;7(12):002085. doi: 10.12890/2020_002085. eCollection 2020.
UNLABELLED
The triad of diabetic ketoacidosis, acute pancreatitis and hypertriglyceridemia is a rare phenomenon, with mortality rates of up to 80%. A unique characteristic of the described case is the co-occurrence of non-immune haemolytic anaemia (NIHA) with the complex triad. It is suggested that this presentation is secondary to hyperlipidemia which leads to increased fragility of erythrocytes due to destabilization of red cell membranes. Supportive treatment with intravenous insulin and blood transfusions is the cornerstone of treatment.
LEARNING POINTS
The enigmatic triangle of diabetic ketoacidosis (DKA), hypertriglyceridemia and acute pancreatitis is a rare phenomenon occurring in only 4% of DKA cases.This triad can be complicated by non-immune haemolytic anaemia secondary to hyperlipidemia, which leads to increased fragility of the erythrocyte due to destabilization of red cell membranes.Supportive treatment with intravenous insulin administration and blood transfusions is the cornerstone of treatment.
未标注
糖尿病酮症酸中毒、急性胰腺炎和高甘油三酯血症三联征是一种罕见现象，死亡率高达80%。所述病例的一个独特特征是，非免疫性溶血性贫血（NIHA）与这一复杂三联征同时出现。有人认为，这种表现是高脂血症的继发结果，高脂血症会因红细胞膜不稳定而导致红细胞脆性增加。静脉注射胰岛素和输血的支持性治疗是治疗的基石。
学习要点
糖尿病酮症酸中毒（DKA）、高甘油三酯血症和急性胰腺炎这一神秘三联征是一种罕见现象，仅在4%的DKA病例中出现。这种三联征可能因高脂血症继发非免疫性溶血性贫血而复杂化，高脂血症会因红细胞膜不稳定而导致红细胞脆性增加。静脉注射胰岛素给药和输血的支持性治疗是治疗的基石。
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