Medical School of Chinese PLA, Beijing, People's Republic of China.
Institute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma and War Injuries, PLA, Beijing, People's Republic of China.
Stem Cells Transl Med. 2021 Jul;10(7):1008-1020. doi: 10.1002/sctm.20-0290. Epub 2021 Feb 15.
Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate the biological behaviors of MSCs. The effects of nerve growth factor (NGF) and its two receptors, TrkA and p75NTR, on neural cells are well studied. Increasing evidence shows that NGF, TrkA, and p75NTR are also involved in various aspects of MSC function, including their survival, growth, differentiation, and angiogenesis. The regulatory effect of NGF on MSCs is thought to be achieved mainly through its binding to TrkA. p75NTR, another receptor of NGF, is regarded as a novel surface marker of MSCs. This review provides an overview of advances in understanding the roles of NGF and its receptors in MSCs as well as the effects of MSC-derived NGF on other cell types, which will provide new insight for the optimization of MSC-based therapy.
间充质干细胞（MSCs）在退行性疾病和创伤性损伤的治疗中有很大的应用前景。然而，MSC 的植入并不总是成功的，需要深入了解细胞因子及其受体，这些细胞因子和受体介导 MSC 的生物学行为。神经生长因子（NGF）及其两个受体 TrkA 和 p75NTR 对神经细胞的作用已经得到了很好的研究。越来越多的证据表明，NGF、TrkA 和 p75NTR 也参与了 MSC 功能的各个方面，包括它们的存活、生长、分化和血管生成。NGF 对 MSCs 的调节作用被认为主要是通过其与 TrkA 的结合来实现的。p75NTR，NGF 的另一个受体，被认为是 MSCs 的一个新型表面标志物。本综述概述了对 NGF 及其受体在 MSCs 中的作用以及 MSC 衍生的 NGF 对其他细胞类型的影响的理解进展，这将为基于 MSC 的治疗的优化提供新的见解。
