Pertschuk L P, Moccia L F, Rosen Y, Lyons H, Marino C M, Rashford A A, Wollschlager C M
Am J Clin Pathol. 1977 Nov;68(5):553-7. doi: 10.1093/ajcp/68.5.553.
Lung tissue obtained from eight consecutive patients with systemic lupus erythematosus complicated by severe, acute pulmonary disease was studied by both light and immunofluorescence microscopy. Light microscopic examination disclosed interstitial pneumonia in four cases, cytomegalovirus pneumonitis in one case, bronchiolitis and peribronchiolitis in one case, pulmonary infarction in one case and focal atelectasis in the remaining case. Direct immunofluorescence examination revealed focally bound immunoglobulins or complement (C3) within pleural and/or pneumocyte nuclei in each specimen. Immunohistologic studies in these cases may thus suggest a diagnosis of systemic lupus erythematosus with acute pulmonary complications, despite the lack of specificity of the pathologic changes seen by light microscopy.
对连续8例患有系统性红斑狼疮并伴有严重急性肺部疾病的患者的肺组织进行了光镜和免疫荧光显微镜检查。光镜检查发现4例为间质性肺炎，1例为巨细胞病毒性肺炎，1例为细支气管炎和细支气管周围炎，1例为肺梗死，其余1例为局灶性肺不张。直接免疫荧光检查显示，每个标本的胸膜和/或肺细胞核内有局灶性结合的免疫球蛋白或补体（C3）。因此，尽管光镜下所见的病理改变缺乏特异性，但这些病例的免疫组织学研究可能提示系统性红斑狼疮合并急性肺部并发症的诊断。
