Department of Otolaryngology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA.
Otolaryngol Head Neck Surg. 2021 Nov;165(5):611-616. doi: 10.1177/0194599820987827. Epub 2021 Feb 16.
The popularity of nonsurgical rhinoplasty with injectable fillers continues to rise, and it is important to understand the scope of potential adverse outcomes. The purpose of our study is to determine the prevalence and types of adverse outcomes secondary to nonsurgical rhinoplasty.
PubMed, Cochrane, Embase.
The data sources were explored using the following combination of terms: (("inject*" OR "nonsurgical" OR "augmentation" OR "filler") AND "rhinoplast*") AND ("complication" OR "adverse" OR "embol*"). Studies on human nonsurgical rhinoplasty using injectable fillers were included. A quantitative meta-analysis was performed on articles with low risk of bias.
The search yielded 37 publications for review, with 23 included cohort studies and 14 case reports with 8604 patients undergoing nonsurgical rhinoplasty with reported complications. The overall rate of adverse outcome across all cohort studies was 2.52%. The most commonly reported complications were bruising (1.58%) and hematoma (0.13%). While uncommon, there are several reports of major complications including 30 episodes of vessel occlusion (0.35%), 7 reports of skin necrosis (0.08%), 8 reports of vision loss (0.09%), and 6 reports of infection (0.07%).
Overall, nonsurgical rhinoplasty with injectable fillers is safe with low rates of complications. However, serious complications, such as vision loss, skin necrosis, and vessel occlusion, can occur. Further studies are needed to optimize delivery of injectable fillers in the nose to decrease the rate of adverse outcomes.
注射填充剂的非手术隆鼻术越来越受欢迎，了解潜在不良后果的范围很重要。我们研究的目的是确定非手术隆鼻术继发不良后果的发生率和类型。
PubMed、Cochrane、Embase。
使用以下组合术语探索资料来源：（（“注射”或“非手术”或“增强”或“填充物”）和“隆鼻术”）和（“并发症”或“不良”或“栓塞”）。纳入了使用注射填充剂进行非手术隆鼻术的人类研究。对偏倚风险低的文章进行了定量荟萃分析。
搜索结果为 37 篇文章进行综述，其中 23 项为队列研究，14 项为病例报告，共 8604 例患者接受了注射填充剂的非手术隆鼻术，并报告了并发症。所有队列研究中不良后果的总体发生率为 2.52%。最常见的报告并发症是瘀伤（1.58%）和血肿（0.13%）。虽然不常见，但有几例严重并发症的报告，包括 30 例血管闭塞（0.35%）、7 例皮肤坏死（0.08%）、8 例视力丧失（0.09%）和 6 例感染（0.07%）。
总体而言，注射填充剂的非手术隆鼻术安全性高，并发症发生率低。然而，严重的并发症，如视力丧失、皮肤坏死和血管闭塞，可能会发生。需要进一步研究以优化在鼻子中注射填充剂的应用，以降低不良后果的发生率。
