亚极量运动和冷暴露对冠心病患者凝血参数的影响。
The effects of submaximal exercise and cold exposure on blood coagulation parameters in coronary artery disease patients.
机构信息
Center for Environmental and Respiratory Health Research (CERH), University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland.
出版信息
BMC Cardiovasc Disord. 2021 Feb 16;21(1):93. doi: 10.1186/s12872-021-01907-9.
BACKGROUND
Both exercise and cold exposure increase blood coagulation potential but their combined effects are not known. The purpose of the present study was to assess blood coagulation factors in response to submaximal exercise in the cold environment among patients with stable coronary artery disease (CAD).
METHODS
Sixteen men (61.1 ± 7.1 years) with stable CAD participated in three 30-min experimental conditions (seated rest in - 15 °C and exercise in both + 22 °C and - 15 °C) in random order. The employed exercise consisted of brisk walking (66-69% of maximal heart rate). Factor VII (FVII), fibrinogen, D-dimer and von Willebrand factor (vWF) were analyzed from blood samples obtained before, immediately and one hour after each experiment.
RESULTS
On average, FVII activity (95% confidence interval, CI) was 123 (108-143) %, 123 (106-140) %, 121 (103-139) % (baseline, recovery 1, recovery 2), fibrinogen concentration (95% CI) 3.81 (3.49-4.12) g/l, 3.71 (3.34-4.08) g/l, 3.65 (3.26-4.05) g/l, D-dimer concentration (95% CI) 0.42 (0.28-0.56) µg/ml, 0.42 (0.29-.55) µg/ml and 0.39 (0.29-0.49) µg/ml, and vWF activity (95% CI) 184 (135-232) %, 170 (128-212) % and 173 (129-217) % after exercise in the cold. Average FVII activity varied from 122 to 123%, fibrinogen concentration from 3.71 to 3.75 g/l, D-dimer concentration from 0.35 to 0.51 µg/ml and von Willebrand factor activity from 168 to 175% immediately after each three experimental condition.
CONCLUSIONS
Our findings suggest that submaximal lower body exercise carried out in a cold environment does not significantly affect blood coagulation parameters among patients with stable CAD.
背景
运动和冷暴露都会增加血液凝固的可能性，但它们的综合作用尚不清楚。本研究的目的是评估稳定型冠状动脉疾病（CAD）患者在寒冷环境下进行亚最大强度运动时的血液凝固因子。
方法
16 名男性（61.1±7.1 岁）患有稳定型 CAD，随机参与三种 30 分钟的实验条件（-15°C 下静坐休息和在+22°C 和-15°C 下运动）。所采用的运动是轻快的步行（最大心率的 66-69%）。在每个实验前后，分别从血液样本中分析因子 VII（FVII）、纤维蛋白原、D-二聚体和血管性血友病因子（vWF）。
结果
平均而言，FVII 活性（95%置信区间，CI）为 123（108-143）%、123（106-140）%、121（103-139）%（基线、恢复 1、恢复 2），纤维蛋白原浓度（95%CI）为 3.81（3.49-4.12）g/L、3.71（3.34-4.08）g/L、3.65（3.26-4.05）g/L、D-二聚体浓度（95%CI）为 0.42（0.28-0.56）μg/ml、0.42（0.29-0.55）μg/ml 和 0.39（0.29-0.49）μg/ml，vWF 活性（95%CI）为 184（135-232）%、170（128-212）%和 173（129-217）%，在寒冷环境下进行亚最大强度运动后。平均 FVII 活性在 122%至 123%之间变化，纤维蛋白原浓度在 3.71 至 3.75 g/L 之间变化，D-二聚体浓度在 0.35 至 0.51μg/ml 之间变化，血管性血友病因子活性在 168%至 175%之间变化。
结论
我们的研究结果表明，在寒冷环境下进行亚最大强度下肢运动不会显著影响稳定型 CAD 患者的血液凝血参数。
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