School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Int J Environ Res Public Health. 2021 Oct 11;18(20):10618. doi: 10.3390/ijerph182010618.
Firefighting rescues are high-hazard activities accompanied by uncertainty, urgency, and complexity. Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. The urine samples of ten firefighters were collected before and after the simulated firefighting, and the proteins in urine samples were identified by the liquid chromatography-mass spectroscopy. Blood lactate and heart rate were measured. There were 360 proteins up-regulated and 265 proteins downregulated after this simulated firefighting. Changes in protein expression were significantly related to acute inflammatory responses, immune responses, complement activation, and oxidative stress. Beta-2-microglobulin (r = 0.76, < 0.05) and von Willebrand factors (r = 0.81, < 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67, < 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters.
消防救援是伴随着不确定性、紧迫性和复杂性的高风险活动。了解消防救援过程中的代谢特征具有重要价值。本研究旨在更深入地探讨消防救援引起的生理反应。在模拟消防救援前后，采集了 10 名消防员的尿液样本，并通过液相色谱-质谱联用技术对尿液样本中的蛋白质进行了鉴定。同时，测量了血乳酸和心率。模拟消防救援后，有 360 种蛋白质上调，265 种蛋白质下调。蛋白质表达的变化与急性炎症反应、免疫反应、补体激活和氧化应激显著相关。β-2-微球蛋白（r = 0.76， < 0.05）和血管性血友病因子（r = 0.81， < 0.01）与模拟消防救援时的心率呈正相关，碳酸酐酶 1（r = 0.67， < 0.05）与模拟消防救援后的血乳酸呈正相关。这些结果表明，β-2-微球蛋白、血管性血友病因子和碳酸酐酶 1可以作为评估消防员运动强度的重要指标。
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