Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, South Korea.
Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, South Korea.
Carbohydr Polym. 2021 Apr 15;258:117705. doi: 10.1016/j.carbpol.2021.117705. Epub 2021 Jan 30.
Self-healing, thermo-responsive hydrogels have received increasing attention for tissue engineering, drug delivery, and cosmetic applications. Here, a thermo-responsive hydrogel with self-healing properties was prepared from methylcellulose (MC) and a water-soluble chitosan oligomer (CHI-O). First, dialdehyde methylcellulose (DAMC) derivative was synthesized from MC via periodate oxidation, and its rheological behavior was investigated according to the degree of oxidation. Next, dual-crosslinked DAMC/CHI-O copolymer hydrogels were obtained via Schiff base formation between the aldehyde group of DAMC and the amino group of CHI-O. These hydrogels were chemically linked by imine bonds and physically linked through hydrophobic interactions originating from MC. Based on rheological and compression tests, the gelation rate, mechanical properties, and self-healing properties of the copolymer hydrogels are compared with those of the MC hydrogel. Finally, the release of model compounds (adenosine and l-ascorbic acid) from the DAMC/CHI-O copolymer hydrogel was studied as a preliminary test for cosmetic applications.
自修复、温敏水凝胶因其在组织工程、药物输送和化妆品应用等方面的应用而受到越来越多的关注。在这里，通过甲基纤维素（MC）和水溶性壳聚糖低聚物（CHI-O）制备了具有自修复性能的温敏水凝胶。首先，通过高碘酸盐氧化法从 MC 合成了二醛甲基纤维素（DAMC）衍生物，并根据氧化程度研究了其流变行为。接下来，通过 DAMC 中的醛基与 CHI-O 中的氨基之间的席夫碱形成，得到了双交联 DAMC/CHI-O 共聚物水凝胶。这些水凝胶通过亚胺键化学交联，并通过源自 MC 的疏水相互作用物理交联。基于流变学和压缩测试，比较了共聚物水凝胶的胶凝速率、力学性能和自修复性能与 MC 水凝胶的性能。最后，作为化妆品应用的初步测试，研究了模型化合物（腺苷和 l-抗坏血酸）从 DAMC/CHI-O 共聚物水凝胶中的释放情况。
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