成人急性白血病患者及其家属的焦虑、抑郁状况及其与生活质量的比较：一项在中国的横断面研究。

Comparison of the anxiety, depression and their relationship to quality of life among adult acute leukemia patients and their family caregivers: a cross-sectional study in China.

机构信息

The School of Nursing, Fujian Medical University, Fuzhou, China.

Department of Hematology, The First Affiliated Hospital of Fujian University, NO.1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou City, 350122, Fujian Province, China.

出版信息

Qual Life Res. 2021 Jul;30(7):1891-1901. doi: 10.1007/s11136-021-02785-6. Epub 2021 Feb 17.

DOI:10.1007/s11136-021-02785-6

PMID:33595826

Abstract

PURPOSE

To compare the anxiety, depression and explore their relationship to quality of life (QoL) among adult acute leukemia (AL) patients and family caregivers (FCs) in China.

METHODS

A multicenter cross-sectional study was conducted from April 2017 to January 2018. The sample comprised 207 dyads of adult AL patients and FCs. The participants were required to complete socio-demographic information and the Hospital Anxiety and Depression Scale (HADS). The Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu, only for patients) and MOS 36-item Short-Form Health Survey (SF-36, only for FCs) were used to measure QoL.

RESULTS

The mean scores of anxiety and depression for AL patients were 7.89 ± 3.85 and 7.18 ± 4.23, respectively. For FCs, the mean scores of anxiety and depression were 9.96 ± 3.73 and 8.64 ± 3.74. In this study, adult AL Patients' sex, patients' depression score, whether patients achieving a CR or not, education, FCs' depression score, patients' social/family well-being and emotional well-being were significantly associated with patients' anxiety or depression (p < 0.05). For FCs, depression was significantly related to the physical component summary (β = 0.127, p = 0.008). There were significant differences in anxiety (t = - 5.92, p < 0.001) and depression (t = - 4.19, p < 0.001) between patients and FCs.

CONCLUSIONS

AL patients' FCs showed higher score of anxiety and depression than that of patients. The psychological health may have a potential relationship between AL patients and their FCs. Healthcare professionals can conduct family-center interventions to improve mental health and QoL of AL patients and FCs.

摘要

目的

比较中国成人急性白血病（AL）患者及其家属的焦虑、抑郁状况，并探讨其与生活质量（QoL）的关系。

方法

采用多中心横断面研究方法，于 2017 年 4 月至 2018 年 1 月选取 207 对成年 AL 患者及其家属进行问卷调查。患者和家属均需填写一般人口学资料和医院焦虑抑郁量表（HADS）。采用癌症治疗功能评价-白血病量表（FACT-Leu，仅用于患者）和 MOS 36 项简短健康调查问卷（SF-36，仅用于家属）评估 QoL。

结果

AL 患者焦虑和抑郁的平均得分为 7.89±3.85 分和 7.18±4.23 分，家属的焦虑和抑郁平均得分为 9.96±3.73 分和 8.64±3.74 分。本研究中，患者的性别、抑郁评分、是否达到完全缓解、文化程度、家属的抑郁评分、患者的社会/家庭状况和情绪状况与患者的焦虑或抑郁显著相关（p<0.05）。对于家属，抑郁与生理健康维度得分显著相关（β=0.127，p=0.008）。患者的焦虑和抑郁得分显著高于家属（t=-5.92，p<0.001；t=-4.19，p<0.001）。