Huan Yu, Mujun Xiong, Xin Liao, Ping Zhu, Limei Fu, Aming Lei, Xinquan Liang
Department of Hematology, Chenzhou First People's Hospital, Chenzhou City, Hunan Province, People's Republic of China.
Neuropsychiatr Dis Treat. 2022 Jul 29;18:1573-1582. doi: 10.2147/NDT.S362229. eCollection 2022.
Our study aimed to investigate the level of depression, anxiety, and fatigue in patients with leukemias, and analyze the influence of sleep duration on the mental symptoms of patients with leukemias.
A total of 127 patients were enrolled in our study and completed the questionnaire survey. Self-Assessment Depression Scale (SDS), Self-Assessment Anxiety Scale (SAS), and the Fatigue Scale-14 (FS-14) were adopted. The patient's lifestyle information, including exercise, alcohol abuse, and smoking, was obtained from the patient's self-report.
Depression score of patients with sleep duration >8 hours (long duration group) was 56.21±11.63, which was significantly lower than that of patients sleep duration between 6 and 8 hours (medium duration group) with 59.61±8.77 and patients sleep <6 hours (short duration group) with 64.82±6.42 (P = 0.007). Similarly, the anxiety score of long duration group, medium duration group and short duration group was 45.36±11.41, 48.26±6.96 and 53.53±5.87, respectively (P = 0.005). The fatigue score of short duration group is 8.47±2.45, which is higher than others (P = 0.046). To further identify the relationship, we evaluated physical fatigue and mental fatigue levels in patients with or without symptoms of depression. We found that patients with symptoms of depression have a higher score both in physical fatigue and mental fatigue (all p < 0.001). Similar trend was observed in patients with or without symptoms of anxiety (all p < 0.001). However, alzhough patients with leukemia in long duration group have the highest score of physical fatigue (p = 0.016), no significant difference in mental fatigue was found in different sleeping duration group (p = 0.587). Furthermore, multivariate analyses were conducted and revealed that sleep duration was the independent factor associated with depression (OR = 0.270, P = 0.003) and anxiety (OR = 0.473, P = 0.010).
For leukemia patients with short sleep duration, a prompt evaluation of their level of depression, anxiety, and fatigue and the initiation of timely interventions is essential.
本研究旨在调查白血病患者的抑郁、焦虑和疲劳水平，并分析睡眠时间对白血病患者精神症状的影响。
本研究共纳入127例患者并完成问卷调查。采用自评抑郁量表（SDS）、自评焦虑量表（SAS）和疲劳量表-14（FS-14）。患者的生活方式信息，包括运动、酗酒和吸烟情况，通过患者自我报告获得。
睡眠时间>8小时的患者（长时睡眠组）抑郁评分为56.21±11.63，显著低于睡眠时间在6至8小时的患者（中时睡眠组）的59.61±8.77以及睡眠时间<6小时的患者（短时睡眠组）的64.82±6.42（P = 0.007）。同样，长时睡眠组、中时睡眠组和短时睡眠组的焦虑评分分别为45.36±11.41、48.26±6.96和53.53±5.87（P = 0.005）。短时睡眠组的疲劳评分为8.47±2.45，高于其他组（P = 0.046）。为进一步明确关系，我们评估了有或无抑郁症状患者的身体疲劳和精神疲劳水平。我们发现有抑郁症状的患者在身体疲劳和精神疲劳方面得分均更高（均P < 0.001）。在有或无焦虑症状的患者中也观察到类似趋势（均P < 0.001）。然而，尽管长时睡眠组的白血病患者身体疲劳得分最高（P = 0.016），但不同睡眠时间组在精神疲劳方面未发现显著差异（P = 0.587）。此外，进行多因素分析显示睡眠时间是与抑郁（OR = 0.270，P = 0.003）和焦虑（OR = 0.473，P = 0.010）相关的独立因素。
对于睡眠时间短的白血病患者，及时评估其抑郁、焦虑和疲劳水平并及时进行干预至关重要。
