Department of Oral Pathology, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.
Laboratory of Histological Techniques, Department of Morphology, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.
Biotech Histochem. 2021 Nov;96(8):608-615. doi: 10.1080/10520295.2021.1882699. Epub 2021 Feb 19.
We investigated elastofibromas (EF) and elastofibroma-like structures (EFL) in 95 cases that had been diagnosed as oral fibromas (OF). Histological sections were stained with Verhoeff-Van Gieson, Congo red and hematoxylin and eosin to enable possible reclassification to EF or EFL, or to retain the diagnosis of OF. To do this, we identified amyloid and used histopathological descriptions and epidemiological clinical profiles. We found 56 EF and 21 EFL cases, while 18 diagnoses of OF were retained. We observed a predilection for EF in females. Also, the most common site for OF was the cheek mucosa. We also found a longer time course for lesion development for OF compared to the other lesions. We found a relation between elastic fibers and amyloid material in EF. We also observed perivascular fibrotic lesions (PVFL) in EF. Most cases of EF exhibited more elastic fibers, thicker fibers, stronger relation with amyloid material deposition, rare evidence of PVFL and a longer time course for development compared to the other lesions. We suggest that EFL may give rise to oral EF.
我们研究了 95 例被诊断为口腔纤维瘤（OF）的病例中的弹性纤维瘤（EF）和弹性纤维瘤样结构（EFL）。组织切片用 Verhoeff-Van Gieson、刚果红和苏木精-伊红染色，以便可能重新分类为 EF 或 EFL，或保留 OF 的诊断。为此，我们确定了淀粉样蛋白，并使用了组织病理学描述和流行病学临床特征。我们发现 56 例 EF 和 21 例 EFL 病例，而保留了 18 例 OF 的诊断。我们观察到 EF 在女性中更倾向发生。此外，OF 最常见的部位是颊粘膜。我们还发现 OF 的病变发展时间比其他病变更长。我们发现 EF 中的弹性纤维与淀粉样物质之间存在关系。我们还观察到 EF 中的血管周围纤维性病变（PVFL）。大多数 EF 病例表现出更多的弹性纤维、更厚的纤维、与淀粉样物质沉积的更强关系、PVFL 的罕见证据以及与其他病变相比更长的发展时间。我们建议 EFL 可能导致口腔 EF。
