Mihai Ioana Florina, Manciuc Carmen, Hunea Ioana Maria, Lacatusu Georgiana Alexandra, Leonte Georgiana Enache, Luca Stefana, Harja-Alexa Ioana Alina, Vata Andrei, Luca Mihaela Catalina
Department of Infectious Diseases, 'Sf. Parascheva' Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania.
Department of Infectious Diseases, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Exp Ther Med. 2021 Mar;21(3):274. doi: 10.3892/etm.2021.9705. Epub 2021 Jan 25.
While the incidence of hepatitis A virus (HAV) infections has decreased in the last few years, the incidence of hepatitis E virus (HEV) is increasing in developed countries. Both infections remain a worldwide reality, strongly related to socio-economic conditions. We retrospectively analyzed the medical files of patients with viral hepatitis hospitalized in the Infectious Disease Hospital Iasi, Romania between 2018 and 2019. The serological confirmed cases of HAV and HEV infections were included in the analysis; included in our analysis were 269 HAV-infected patients. The most affected were males (53.9% cases) aged between 8 and 15 years (53.6% cases). Severe infections were recorded at admission in 2.24% cases and evolution was favorable under supportive and symptomatic treatment. Only three adult males, with no recent history of travel, were confirmed with HEV infection. Even though we have identified a small number of cases, recent studies performed in our region found a seroprevalence of 32.5% in the general population, possibly related to zoonotic transmission. While outbreaks of HAV infection are still noted in our region, a lack of hospitalized HEV-infected patients suggest that most cases are asymptomatic or underdiagnosed. HEV infection remains an underreported disease, possibly due to misdiagnosis, subclinical or dual hepatitis infection, but with a significant risk in vulnerable categories, such as pregnant women or immunosuppressed patients.
尽管甲型肝炎病毒（HAV）感染的发病率在过去几年有所下降，但戊型肝炎病毒（HEV）在发达国家的发病率却在上升。这两种感染在全球范围内依然存在，与社会经济状况密切相关。我们回顾性分析了2018年至2019年期间在罗马尼亚雅西传染病医院住院的病毒性肝炎患者的病历。血清学确诊的HAV和HEV感染病例被纳入分析；我们分析了269例HAV感染患者。受影响最大的是年龄在8至15岁之间的男性（占病例的53.9%）（占病例的53.6%）。入院时记录的严重感染病例占2.24%，在支持性和对症治疗下病情好转。只有三名近期无旅行史的成年男性被确诊为HEV感染。尽管我们只发现了少数病例，但我们地区最近的研究发现普通人群中的血清阳性率为32.5%，这可能与人畜共患病传播有关。虽然我们地区仍有HAV感染的暴发，但缺乏住院的HEV感染患者表明大多数病例无症状或诊断不足。HEV感染仍然是一种报告不足的疾病，可能是由于误诊、亚临床或双重肝炎感染，但在孕妇或免疫抑制患者等易感人群中有很大风险。
